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Merck
CN

89870

Toluene 2,4-diisocyanate

purum, suitable for electron microscopy, ≥98.0% (GC)

Synonym(s):

2,4-Diisocyanatotoluene, 4-Methyl-m-phenylene diisocyanate, Tolylene 2,4-diisocyanate

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About This Item

Empirical Formula (Hill Notation):
C9H6N2O2
CAS Number:
584-84-9
Molecular Weight:
174.16
UNSPSC Code:
12352200
NACRES:
NA.25
PubChem Substance ID:
57653363
EC Number:
209-544-5
Beilstein/REAXYS Number:
744602
MDL number:
MFCD00002011
Assay:
≥98.0% (GC)
Form:
liquid

Key Documents

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InChI key

DVKJHBMWWAPEIU-UHFFFAOYSA-N

InChI

1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

SMILES string

Cc1ccc(cc1N=C=O)N=C=O

grade

purum

assay

≥98.0% (GC)

form

liquid

technique(s)

electron microscopy: suitable

refractive index

n20/D 1.567

bp

124-126 °C/18 mmHg (lit.), 251 °C (lit.)

mp

19.5-21.5 °C (lit.)

density

1.21 g/mL at 20 °C, 1.22 g/mL at 20 °C (lit.)

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Application

Toluene 2,4-diisocyanate is used to study it occupational hazards (asthma, dermatitis) and mechanisms of action. Reagent for covalent protein crosslinking; For the immobilization of antibodies to a plastic surface for RIA

Other Notes

Reagent for covalent protein crosslinking; For the immobilization of antibodies to a plastic surface for RIA

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

flash_point_f

269.6 °F - closed cup

flash_point_c

132 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

非剧毒-急性毒性1
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Certificates of Analysis (COA)

Lot/Batch Number
BCCB8796
BCBW4648
BCBV7488
BCBV5353
BCBT3797

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T Saito et al.
Clinica chimica acta; international journal of clinical chemistry, 133(3), 301-310 (1983-10-14)
A novel procedure to fix antibody on a plastic surface was developed, using a polystyrene tube treated with 0.5% toluene 2,4-diisocyanate (TC) dissolved in carbon tetrachloride. Using 125I-labelled IgG, we found that the rate of immobilization of IgG was significantly
Shuyu Chen et al.
Allergy, asthma & immunology research, 12(4), 608-625 (2020-05-14)
Accumulating evidence has suggested that toll-like receptor 4 (TLR4) is critically involved in the pathogenesis of asthma. The aim of this study was to investigate the role of TLR4 in toluene diisocyanate (TDI)-induced allergic airway inflammation. TLR4-/- and wild-type (WT)
[57] Bifunctional reagents.
F Wold
Methods in enzymology, 25, 623-651 (1972-01-01)
Rahul Purwar et al.
Experimental dermatology, 20(9), 709-714 (2011-05-17)
Keratinocytes synthesize complement component 3 (C3) constitutively, and increased expression of C3 has been described during skin inflammation. In this study, we investigated the role of C3 in T cell-mediated allergic contact dermatitis, which is a clinical manifestation of contact
Tatiana Kuznetsova et al.
American journal of hypertension, 28(4), 535-545 (2014-09-23)
The cardio-renal interaction occurs via hemodynamic and humoral factors. Noninvasive assessment of renal hemodynamics is currently possible by assessment of renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms as ((peak systolic velocity - end-diastolic velocity)/peak systolic velocity). Limited
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