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94506

Tetramethylrhodamine-5-maleimide

Name: Tetramethylrhodamine-5-maleimide
Brand: SIGMA

suitable for fluorescence, ≥85% (HPLC)

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₃N₃O₅

CAS Number:

174568-67-3

Molecular Weight:

481.50

UNSPSC Code:

12352116

NACRES:

NA.32

MDL number:

MFCD01311091

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Properties

Quality Level

100

assay

≥85% (HPLC)

form

powder

solubility

DMSO: soluble, methanol: soluble

fluorescence

λ_ex 543 nm; λ_em 575 nm in 0.1 M phosphate pH 7.0

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

N5(C(=O)C=CC5=O)c1cc(c(cc1)C2=C3CC=C(C=C3Oc4c2ccc(c4)N(C)C)N(C)C)C(=O)O

InChI

1S/C28H25N3O5/c1-29(2)16-5-9-20-23(14-16)36-24-15-17(30(3)4)6-10-21(24)27(20)19-8-7-18(13-22(19)28(34)35)31-25(32)11-12-26(31)33/h5-9,11-15H,10H2,1-4H3,(H,34,35)

InChI key

KGFLZYXDJDOIEE-UHFFFAOYSA-N

Description

Application

Tetramethylrhodamine-5-maleimide has been used:

to concentrate the eluate and in labeling to create IRE1LDS112C
to derivatize green fluorescent protein (GFP) on Cys48 for experiments with the extrinsic fluorescent probe
to incubate the single solvent exposed cys mutant to perform protein labeling

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Labeling reagent for protein thiols for cytofluorescence

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Cytofluorescence techniques for the visualization of distinct pools of protein thiols at the single cell level.

Alfonso Pompella et al.

Methods in molecular biology (Clifton, N.J.), 196, 305-312 (2002-08-03)

Effect of the point mutation H148G on GFPmut2 unfolding kinetics by fluorescence spectroscopy

Bosisio C, et al.

Biophysical Chemistry, 157(1-3), 24-32 (2011)

Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity

Fanning SW, et al.,

Nature Communications, 9(1), 2368-2368 (2018)

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Global Trade Item Number

SKU	GTIN
94506-1MG-F	04061826670385
94506-5MG-F	04061833276822