94740
Vanadyl ribonucleoside complexes
powder
Synonym(s):
Ribonucleoside vanadyl complexes, VRC
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.52
Form:
powder
Storage temp.:
−20°C
Product Name
Vanadyl ribonucleoside complexes, BioReagent, Molecular Biology
grade
Molecular Biology
product line
BioReagent
form
powder
suitability
in accordance for ribonuclease inhibition test
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
Vanadyl ribonucleoside complexes are low molecular weight inhibitors of ribonucleases.
Application
Vanadyl ribonucleoside complexes (VDR) are transition state analogs that bind to active sites of many RNases, inhibiting their activity. Because the RNases are not covalently modified by the complexes, VDR must be used at every stage of RNA extraction and purification. However, VDR also inhibit RNA polymerases and in vitro translation and therefore must be removed from final preparation of RNA.
Vanadyl ribonucleoside complexes has been used in hybridization mixture for RNA in situ hybridization.
Biochem/physiol Actions
The vanadyl ribonucleoside complex has the ability to block the formation of ribosomal subunit in Staphylococcus aureus. The complex exhibits anti-microbial activity These complexes also serve as powerful inhibitors of several enzymes with ribonucleolytic activity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Isolation of cytoplasmic RNA: ribonucleoside-vanadyl complexes.
S L Berger
Methods in enzymology, 152, 227-234 (1987-01-01)
Analysis of TMEM174 gene expression in various renal cancer types by RNA in situ hybridization
Zhang X, et al.
Oncology Letters, 8(4), 1693-1696 (2014)
Inhibitors of RNases
Sambrook, J. and Russell, D.W. et al.
Molecular Cloning: A Laboratory Manual, 1, 7-7 (2001)
Tissue array for Tp53, C-myc, CCND1 gene over-expression in different tumors
Liu G Y, et al.
World Journal of Gastroenterology, 14(47), 7199-7199 (2008)
Analysis of AC3-33 gene expression in multiple organ cancer and adjacent normal tissue by RNA in situ hybridization
Hu F, et al.
Oncology Letters, 9(6), 2795-2798 (2015)
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