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Merck
CN

95146

Retinol solution

≥95.0% (HPLC)

Synonym(s):

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol, Axerophthol, Vitamin A alcohol solution, Vitamin A1, all-trans-Retinol

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About This Item

Empirical Formula (Hill Notation):
C20H30O
CAS Number:
68-26-8
Molecular Weight:
286.45
UNSPSC Code:
12352200
PubChem Substance ID:
57653655
eCl@ss:
34058018
EC Number:
203-777-6
Beilstein/REAXYS Number:
403040
MDL number:
MFCD00001552

Key Documents

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InChI key

FPIPGXGPPPQFEQ-OVSJKPMPSA-N

InChI

1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

SMILES string

CC(=C/CO)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C

biological source

human plasma

assay

≥95.0% (HPLC)

form

liquid

color

colorless to very light yellow

mp

62-64°C (solvent free)

storage temp.

2-8°C

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Biochem/physiol Actions

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinol is biological active in a wide range of processes.

Analysis Note

0.25 mg in 1 mL hexane

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Central nervous system, Nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

-14.8 °F

flash_point_c

-26 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBM8323V
BCBM4833V
BCBK5794V
BCBK2757V
BCBH0306V

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Gretchen A Stevens et al.
The Lancet. Global health, 3(9), e528-e536 (2015-08-16)
Vitamin A deficiency is a risk factor for blindness and for mortality from measles and diarrhoea in children aged 6-59 months. We aimed to estimate trends in the prevalence of vitamin A deficiency between 1991 and 2013 and its mortality
K R Norum et al.
The American journal of clinical nutrition, 56(4), 735-744 (1992-10-01)
We discuss vitamin A with emphasis on its absorption, transport, cellular uptake, storage, and intracellular metabolism. Dietary retinyl esters are hydrolyzed to retinol in the intestinal lumen before absorption by enterocytes. Carotenoids are absorbed and then partially converted to retinol
S P Spencer et al.
Science (New York, N.Y.), 343(6169), 432-437 (2014-01-25)
How the immune system adapts to malnutrition to sustain immunity at barrier surfaces, such as the intestine, remains unclear. Vitamin A deficiency is one of the most common micronutrient deficiencies and is associated with profound defects in adaptive immunity. Here
Jacqueline A Jumpsen et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 5(2), 77-84 (2006-03-02)
The objective of this study was to investigate the effect of docosahexaenoic acid (DHA) supplementation on blood and intestinal DHA levels and lung function in mild/moderately affected adult CF patients with the DeltaF508 genotype. Cystic Fibrosis (CF) patients often present
N M Hamdan et al.
Journal of dental research, 92(12 Suppl), 146S-153S (2013-10-26)
People wearing mandibular two-implant overdentures (IOD) chew food with less difficulty than those wearing conventional complete dentures (CD). However, there is still controversy over whether or not this results in better dietary intake. In this randomized clinical trials (RCT), the
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