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Merck
CN

95146

Retinol solution

≥95.0% (HPLC)

Synonym(s):

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol, Axerophthol, Vitamin A alcohol solution, Vitamin A1, all-trans-Retinol

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About This Item

Empirical Formula (Hill Notation):
C20H30O
CAS Number:
68-26-8
Molecular Weight:
286.45
UNSPSC Code:
12352200
PubChem Substance ID:
57653655
eCl@ss:
34058018
EC Number:
203-777-6
Beilstein/REAXYS Number:
403040
MDL number:
MFCD00001552

Key Documents

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InChI key

FPIPGXGPPPQFEQ-OVSJKPMPSA-N

InChI

1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

SMILES string

CC(=C/CO)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C

biological source

human plasma

assay

≥95.0% (HPLC)

form

liquid

color

colorless to very light yellow

mp

62-64°C (solvent free)

storage temp.

2-8°C

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Biochem/physiol Actions

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain.
Retinol is biological active in a wide range of processes.

Analysis Note

0.25 mg in 1 mL hexane

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Central nervous system, Nervous system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

-14.8 °F

flash_point_c

-26 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBM8323V
BCBM4833V
BCBK5794V
BCBK2757V
BCBH0306V

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Gretchen A Stevens et al.
The Lancet. Global health, 3(9), e528-e536 (2015-08-16)
Vitamin A deficiency is a risk factor for blindness and for mortality from measles and diarrhoea in children aged 6-59 months. We aimed to estimate trends in the prevalence of vitamin A deficiency between 1991 and 2013 and its mortality
Frank T Wieringa et al.
The American journal of clinical nutrition, 77(3), 651-657 (2003-02-26)
Deficiencies of iron and vitamin A are prevalent worldwide. Single-micronutrient supplementation is widely used to combat these deficiencies. However, micronutrient deficiencies often occur concurrently, and there are many interactions between micronutrients. This study investigated interactions among 3 important micronutrients--iron, vitamin
Grace M Egeland et al.
Canadian journal of public health = Revue canadienne de sante publique, 95(6), 465-469 (2004-12-30)
Inuit traditional food provides ample amounts of preformed vitamin A. However, the dietary transition away from traditional food raises concerns regarding dietary adequacy. Vitamin A is an essential nutrient with inadequate and excessive exposures having adverse effects. To evaluate total
K R Norum et al.
The American journal of clinical nutrition, 56(4), 735-744 (1992-10-01)
We discuss vitamin A with emphasis on its absorption, transport, cellular uptake, storage, and intracellular metabolism. Dietary retinyl esters are hydrolyzed to retinol in the intestinal lumen before absorption by enterocytes. Carotenoids are absorbed and then partially converted to retinol
Jacqueline A Jumpsen et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 5(2), 77-84 (2006-03-02)
The objective of this study was to investigate the effect of docosahexaenoic acid (DHA) supplementation on blood and intestinal DHA levels and lung function in mild/moderately affected adult CF patients with the DeltaF508 genotype. Cystic Fibrosis (CF) patients often present
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