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96669

7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

Name: 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin
Brand: SIGMA

suitable for fluorescence, BioReagent, ≥90% (HPCE)

Synonym(s):

1H-Pyrrole-2,5-dione, 1-(4-(7-(diethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl)phenyl)-, CPM

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₂N₂O₄

CAS Number:

76877-33-3

Molecular Weight:

402.44

NACRES:

NA.32

PubChem Substance ID:

57653774

UNSPSC Code:

12171500

MDL number:

MFCD00077334

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product line

BioReagent

Quality Level

100

assay

≥90% (HPCE)

form

solid

fluorescence

λ_ex 391 nm; λ_em 472 nm in methanol: 2-mercaptoethanol

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

CCN(CC)c1ccc2C(C)=C(C(=O)Oc2c1)c3ccc(cc3)N4C(=O)C=CC4=O

InChI

1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3

InChI key

YGIABALXNBVHBX-UHFFFAOYSA-N

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Clinical & Diagnostics

Dry Dyes & Certified Stains

Tissue Diagnostics

Application

Fluorescence probe for glutathione for intact cells; specific advantages: only thio derivative fluoresces, high quantum yield and good Stokes shift

Biochem/physiol Actions

Used to monitor release of thiols, quantitate thiol in microplate reactions, and to distinguish proliferating cancer cells by nucleolar protein staining.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Somatosensory assessment and conditioned pain modulation in temporomandibular disorders pain patients.

Simple Futarmal Kothari et al.

Pain, 156(12), 2545-2555 (2015-08-27)

The pathophysiology and underlying pain mechanisms of temporomandibular disorders (TMD) are poorly understood. The aims were to assess somatosensory function at the temporomandibular joints (TMJs) and to examine whether conditioned pain modulation (CPM) differs between TMD pain patients (n =

An essential role for the extracellular domain of the Na,K-ATPase beta-subunit in cation occlusion.

S Lutsenko et al.

Biochemistry, 32(26), 6737-6743 (1993-07-06)

The role of the Na,K-ATPase beta-subunit in stabilization of ion-binding sites has been investigated. Treatment of the purified renal Na,K-ATPase with 0.25 M DTT at 40 degrees C for 1 h resulted in 50% loss of Rb occlusion, which correlates

Effect of Pain Induction or Pain Reduction on Conditioned Pain Modulation in Adults: A Systematic Review.

Dorien Goubert et al.

Pain practice : the official journal of World Institute of Pain, 15(8), 765-777 (2014-11-13)

Pain facilitation as well as pain inhibition might be present in chronic pain patients. A decreased efficacy of pain inhibition can be measured by conditioned pain modulation (CPM). The use of the CPM paradigm in scientific research has boosted over

Direct evidence for the existence and functional role of hyperreactive sulfhydryls on the ryanodine receptor-triadin complex selectively labeled by the coumarin maleimide 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin.

G Liu et al.

Molecular pharmacology, 45(2), 189-200 (1994-02-01)

The fluorogenic sulfhydryl probe 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin (CPM) (1-50 nM) is used to characterize the functional role and location of highly reactive thiol groups on the ryanodine-sensitive Ca2+ release channel complex [i.e., ryanodine receptors (RyRs)] of skeletal and cardiac junctional sarcoplasmic reticulum

Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.

Tamara N Tsalkova et al.

Biochemistry, 46(1), 106-119 (2007-01-03)

Design of a partially cysteine-depleted C98S/C239S/C377S/C468A cytochrome P450 3A4 mutant designated CYP3A4(C58,C64) allowed site-directed incorporation of thiol-reactive fluorescent probes into alpha-helix A. The site of modification was identified as Cys-64 with the help of CYP3A4(C58) and CYP3A4(C64), each bearing only

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Global Trade Item Number

SKU	GTIN
96669-10MG-F	04061833488676

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