A6566
2-Hydroxysaclofen
≥98% (TLC), solid
Synonym(s):
3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid
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About This Item
Empirical Formula (Hill Notation):
C9H12ClNO4S
CAS Number:
Molecular Weight:
265.71
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (TLC)
form
solid
color
white
solubility
H2O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL
SMILES string
NCC(O)(CS(O)(=O)=O)c1ccc(Cl)cc1
InChI
1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)
InChI key
WBSMZVIMANOCNX-UHFFFAOYSA-N
Gene Information
human ... GABBR1(2550), GABBR2(9568)
Biochem/physiol Actions
Potent and selective antagonist at GABAB receptors.
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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K Obrietan et al.
Journal of neurophysiology, 82(1), 94-102 (1999-07-13)
In the mature nervous system excitatory neurotransmission mediated by glutamate is balanced by the inhibitory actions of GABA. However, during early development, GABA acting at the ligand-gated GABAA Cl- channel also exerts excitatory actions. This raises a question as to
Jacques H Abraini et al.
Anesthesia and analgesia, 96(3), 746-749 (2003-02-25)
Inhaled anesthetics, including the gaseous anesthetics nitrous oxide and xenon, are thought to act by interacting directly with ion-channel receptors. In contrast, little is known about the mechanism of action of inert gases that show only narcotic potency at high
María M Bonaventura et al.
European journal of pharmacology, 677(1-3), 188-196 (2012-01-03)
γ-Aminobutyric acid (GABA) inhibits insulin secretion through GABA(B) receptors in pancreatic β-cells. We investigated whether GABA(B) receptors participated in the regulation of glucose homeostasis in vivo. BALB/c mice acutely pre-injected with the GABA(B) receptor agonist baclofen (7.5mg/kg, i.p.) presented glucose
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A6566-2.5MG | 04061833002001 |