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Merck
CN

A6566

2-Hydroxysaclofen

≥98% (TLC), solid

Synonym(s):

3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid

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About This Item

Empirical Formula (Hill Notation):
C9H12ClNO4S
CAS Number:
117354-64-0
Molecular Weight:
265.71
NACRES:
NA.32
PubChem Substance ID:
24278170
UNSPSC Code:
12352200
MDL number:
MFCD00069282

Key Documents

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Product Name

2-Hydroxysaclofen, ≥98% (TLC), solid

InChI

1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)

SMILES string

NCC(O)(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI key

WBSMZVIMANOCNX-UHFFFAOYSA-N

assay

≥98% (TLC)

form

solid

color

white

solubility

H2O: 1 mg/mL
0.1 M HCl: 1.2 mg/mL
methanol: 1.4 mg/mL
DMSO: 28 mg/mL
0.1 M NaOH: 9.5 mg/mL

Quality Level

200

Gene Information

human ... GABBR1(2550), GABBR2(9568)

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Related Categories

Biochem/physiol Actions

Potent and selective antagonist at GABAB receptors.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000357420
0000357420
071M1618V
037K3786
054K3789

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D R Curtis et al.
Neuroscience letters, 92(1), 97-101 (1988-09-23)
When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the
K Obrietan et al.
Journal of neurophysiology, 82(1), 94-102 (1999-07-13)
In the mature nervous system excitatory neurotransmission mediated by glutamate is balanced by the inhibitory actions of GABA. However, during early development, GABA acting at the ligand-gated GABAA Cl- channel also exerts excitatory actions. This raises a question as to
Jacques H Abraini et al.
Anesthesia and analgesia, 96(3), 746-749 (2003-02-25)
Inhaled anesthetics, including the gaseous anesthetics nitrous oxide and xenon, are thought to act by interacting directly with ion-channel receptors. In contrast, little is known about the mechanism of action of inert gases that show only narcotic potency at high
K Seki et al.
The Journal of physiology, 533(Pt 2), 503-518 (2001-06-05)
1. To investigate the mechanisms for the coding stimulus sequence in the auditory cortex (AC), post-tetanic potentiation (PTP) was recorded after sequentially combined heterosynaptic stimulation was applied in rat AC slices. 2. Brief tetanic stimulation (TS) was applied at two
María M Bonaventura et al.
European journal of pharmacology, 677(1-3), 188-196 (2012-01-03)
γ-Aminobutyric acid (GABA) inhibits insulin secretion through GABA(B) receptors in pancreatic β-cells. We investigated whether GABA(B) receptors participated in the regulation of glucose homeostasis in vivo. BALB/c mice acutely pre-injected with the GABA(B) receptor agonist baclofen (7.5mg/kg, i.p.) presented glucose
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