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Merck
CN

L8912

L-Leucine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, JP, USP testing specifications

Synonym(s):

(S)-Leucine, (S)-2-Amino-4-methylpentanoic acid

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
61-90-5
Molecular Weight:
131.17
NACRES:
NA.26
PubChem Substance ID:
24896510
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-522-0
MDL number:
MFCD00002617
Beilstein/REAXYS Number:
1721722

Key Documents

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Product Name

L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%

biological source

non-animal source

Quality Level

300

agency

USP/NF, meets EP testing specifications, meets JP testing specifications, meets USP testing specifications

assay

98.5-101.0%

form

powder

optical activity

[α]20/D 14.9 to 16.0°, c = 4 in 6 M HCl, [α]25/D 14.9 to 17.3 °, c = 4 in 6 M HCl

quality

meets EP, JP, USP testing specifications

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

>300 °C (lit.)

solubility

1 M HCl: 50 mg/mL

cation traces

As: ≤1 ppm, Fe: ≤10 ppm, NH4+: <0.02%, heavy metals: ≤10 ppm

application(s)

peptide synthesis
pharmaceutical (small molecule)

functional group

amine, carboxylic acid

storage temp.

room temp

SMILES string

CC(C)C[C@H](N)C(O)=O

InChI

1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1

InChI key

ROHFNLRQFUQHCH-YFKPBYRVSA-N

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General description

Leucine is a non-glucogenic, and essential amino acid. It is a branched-chain amino acid that is a structural component of proteins.

Application

L-Leucine has been used:

  • as a hypertrophic agent to monitor its effects on myotubes.
  • as a component of PMG media for culturing yeast.
  • in myotube protein synthesis analysis in skeletal muscle cells.
  • to study its effects on hepatic lipid metabolism.

Biochem/physiol Actions

Leucine plays a role in intracellular signaling, gene transcription, and translation. It promotes the synthesis of protein by activating the mammalian target of the rapamycin (mTOR) signaling pathway in placental cells, skeletal muscles, and adipose tissue. Leucine inhibits protein degradation and promotes mitochondrial biogenesis, glucose metabolism, and fatty acid oxidation to provide energy for protein synthesis.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
The product is intended for laboratory use only, and it is not suitable for drug, household, or other purposes.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000535874
0000535873
0000535875
0000529476
0000529477

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Find documentation for the products that you have recently purchased in the Document Library.

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Leucine in Obesity: Therapeutic Prospects
Yao K, et al.
Trends in Pharmacological Sciences, 37(8), 714-727 (2016)
The role of leucine and its metabolites in protein and energy metabolism
Duan Y, et al.
Amino Acids, 48(1), 41-51 (2016)
Optimization of an in vitro bioassay to monitor growth and formation of myotubes in real time
Sylvia M
Bioscience Reports (2016)
(-)-Epicatechin and its colonic metabolite hippuric acid protect against dexamethasone-induced atrophy in skeletal muscle cells
Edwards S J, et al.
The Journal of Nutritional Biochemistry, 110, 109150- 109150 (2022)
Susan A Masino
Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (2016)
View All Related Papers

Global Trade Item Number

SKUGTIN
L8912-10MG04061833966266
L8912-25G04061833966280
L8912-100G04061835546558
L8912-1KG04061833966273

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