A0606
Aurothioglucose hydrate
≥96% (titration), PKCι-Par6 interaction inhibitor, powder
Synonym(s):
Gold thioglucose, Solganal, Solganol
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About This Item
Empirical Formula (Hill Notation):
C6H11AuO5S · xH2O
CAS Number:
Molecular Weight:
392.18 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
EC Number:
235-365-7
Product Name
Aurothioglucose hydrate, ≥96% (titration)
Quality Level
assay
≥96% (titration)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 5 mg/mL, clear
storage temp.
2-8°C
SMILES string
O.OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C6H12O5S.Au.H2O/c7-1-2-3(8)4(9)5(10)6(12)11-2;;/h2-10,12H,1H2;;1H2/q;+1;/p-1/t2-,3-,4+,5-,6-;;/m1../s1
InChI key
SGVIEHTYEMEDRR-PKXGBZFFSA-M
Application
Aurothioglucose hydrate has been used in redox stress survival assay in human cell lines and for inducing obese phenotype in mice.
Biochem/physiol Actions
Aurothioglucose, a gold compound used clinically to treat rheumatoid arthritis, has recently been found to be a potent PKCiota-Par6 interaction inhibitor, with an IC50 approximately 1 μM. Disruption of this interaction disrupts a rac1 signaling pathway that is required for transformed growth in non-small-cell lung cancer.
Potent PKCι-Par6 interaction inhibitor
Features and Benefits
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Articles
Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.
Kouichi Yoshinari et al.
Pharmaceutical research, 23(6), 1188-1200 (2006-05-23)
Changes in physiological, pathophysiological, and/or nutritional conditions often alter the expression of drug-metabolizing enzymes. In this study, we investigated obesity-induced changes in hepatic cytochrome P450 (P450) levels using nutritionally obese mice. To induce obesity, mice were fed a high-fat diet
Eric N van Roon et al.
The Journal of rheumatology, 32(6), 1026-1030 (2005-06-09)
For reasons of insufficient quality of the raw material, aurothioglucose was withdrawn from the Dutch market at the end of 2001. Aurothiomalate became available as an alternative preparation. We followed a cohort of patients during the first year after switching
Mitsunari Ogasawara et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(4), 542-551 (2011-03-09)
The search for effective treatments of non-alcoholic steatohepatitis (NASH), now the most common chronic liver disease in affluent countries, is hindered by a lack of animal models having the range of anthropometric and pathophysiological features as human NASH. To examine
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A0606-25MG | 04061832433738 |
| A0606-5MG | 04061832433745 |