A0966
4-Amino-1,8-naphthalimide
solid
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About This Item
Empirical Formula (Hill Notation):
C12H8N2O2
CAS Number:
Molecular Weight:
212.20
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83
Product Name
4-Amino-1,8-naphthalimide,
form
solid
Quality Level
mp
360 °C
density
1.105 g/mL at 25 °C (lit.)
storage temp.
−20°C
SMILES string
Nc1ccc2C(=O)NC(=O)c3cccc1c23
InChI
1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)
InChI key
SSMIFVHARFVINF-UHFFFAOYSA-N
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Biochem/physiol Actions
4-Amino-1,8-naphthalimide sensitizes cells to radiation-induced cell damage and enhances the cytotoxicity of 1-methyl-3-nitro-1-nitrosoguanidine.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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M Banasik et al.
The Journal of biological chemistry, 267(3), 1569-1575 (1992-01-25)
Two classes of enzymes, poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferases, catalyze covalent attachment of multiple or single residues, respectively, of the ADP-ribose moiety of NAD+ to various proteins. In order to find good inhibitors of poly(ADP-ribose) synthetase free of side actions and
A Schlicker et al.
International journal of radiation biology, 75(1), 91-100 (1999-02-11)
Poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) is a chromatin-bound enzyme which is known to regulate chromatin structure by poly(ADP-ribosyl)ation of nuclear proteins, to facilitate DNA base excision repair, and to contribute to cellular recovery following DNA damage. Because inhibitors of PARP
Marco A Alcala et al.
Nanomedicine : nanotechnology, biology, and medicine, 7(3), 249-258 (2010-10-16)
Surgery is currently the best approach for treating either primary or metastatic hepatic malignancies. Because only 20% of hepatic cancers are operable in patients, several types of regional therapy (RT) are emerging as alternate treatment modalities. However, RTs can have
Emma B Veale et al.
The Journal of organic chemistry, 75(16), 5513-5525 (2010-08-14)
The synthesis and characterization of three bis-1,8-naphthalimide-containing Tröger's bases 1-3, formed from the corresponding 4-amino-1,8-naphthalimide precursors 7-9 in a single step, is described. The photophysical investigation of 1-3 and 7-9 was carried out in various organic solvents as well as
Jun Feng Zhang et al.
Organic letters, 13(5), 1190-1193 (2011-02-09)
A naphthalimide-based highly selective colorimetric and ratiometric fluorescent probe for the fluoride ion displayed both one- and two-photon ratiometric changes. Upon reaction with the F(-) (TBA(+) and Na(+) salts) anion in CH(3)CN as well as in aqueous buffer solution, probe
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