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A1001

N-Acetyl-DL-leucine

Name: N-Acetyl-<SC>DL</SC>-leucine
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₅NO₃

CAS Number:

99-15-0

Molecular Weight:

173.21

UNSPSC Code:

12352200

PubChem Substance ID:

24890490

EC Number:

202-734-9

MDL number:

MFCD00026498

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storage temp.

−20°C

SMILES string

[H][C@@](CC(C)C)(NC(C)=O)C(O)=O

InChI

1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)

InChI key

WXNXCEHXYPACJF-UHFFFAOYSA-N

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

012H0276

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Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial.

Katharina Feil et al.

BMC neurology, 17(1), 7-7 (2017-01-11)

Cerebellar ataxia (CA) is a frequent and often disabling condition that impairs motor functioning and impacts on quality of life (QoL). No medication has yet been proven effective for the symptomatic or even causative treatment of hereditary or non-hereditary, non-acquired

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.

Grant C Churchill et al.

PloS one, 15(2), e0229585-e0229585 (2020-02-29)

The enantiomers of many chiral drugs not only exhibit different pharmacological effects in regard to targets that dictate therapeutic and toxic effects, but are also handled differently in the body due to pharmacokinetic effects. We investigated the pharmacokinetics of the

Modified metabolites mapping by liquid chromatography-high resolution mass spectrometry using full scan/all ion fragmentation/neutral loss acquisition.

Hua Li et al.

Journal of chromatography. A, 1583, 80-87 (2018-11-26)

Modified metabolites play important roles in diagnostic monitoring, oxidative response and physiological regulation. Comprehensive analytical methods are greatly needed for improving the coverage of modified metabolites and studying their physiological function. Here, a novel nontargeted profiling method for mapping modified

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