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A1164

Azaserine

Hybri-Max™, γ-irradiated, 50x, lyophilized powder, BioXtra, suitable for hybridoma

Synonym(s):

O-Diazoacetyl-L-serine

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About This Item

Empirical Formula (Hill Notation):
C5H7N3O4
CAS Number:
115-02-6
Molecular Weight:
173.13
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
24890511
EC Number:
204-061-6
Beilstein/REAXYS Number:
1726602
MDL number:
MFCD00036802
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grade

Hybri-Max™

Quality Level

200

sterility

γ-irradiated

product line

BioXtra

form

lyophilized powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O

InChI

1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1

InChI key

MZZGOOYMKKIOOX-VKHMYHEASA-N

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General description

Chemical structure: amino acid derivatives

Application

For use in hybridoma cell culture applications as a myeloma selection agent. Used to study inhibition of formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.

Biochem/physiol Actions

Azaserine is an antibiotic, generated by Streptomyces fragilis. It is considered as a potential mutation inducing agent. It is known to promote pancreatic cancer and induces adenoma and carcinoma in vivo and in vitro. Azaserine also stimulates kidney and liver tumors in rats.

Preparation Note

Reconstitute contents of vial with 10 mL sterile cell culture medium. Stock solution is sufficient to prepare 500 mL medium. Final working concentration: 5.7 μM azaserine.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL7689
SLCL7689
SLBZ8179
SLBT8226
SLBP0957V

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Antineoplastic and Immunosuppressive Agents, Part 2, 494-494 (2013)
The Pathobiology of Neoplasia, 154-154 (2012)
A J Almeida et al.
Fungal genetics and biology : FG & B, 44(12), 1387-1398 (2007-05-22)
We herein report the development of a molecular toolbox for the dimorphic fungus Paracoccidioides brasiliensis, specifically a more efficient transformation and a gene expression system. We evaluated several parameters that influence Agrobacterium tumefaciens-mediated transformation (ATMT), such as co-cultivation conditions and
Marie Pantaleon et al.
Biology of reproduction, 78(4), 595-600 (2007-11-30)
Although mouse oocytes and cleavage-stage embryos are unable to utilize glucose as a metabolic fuel, they have a specific requirement for a short exposure to glucose prior to compaction. The reason for this requirement has been unclear. In this study
Christiane Bierkamp et al.
The American journal of pathology, 165(6), 2135-2145 (2004-12-08)
The presence of gastrin and cholecystokinin-2 (CCK2) receptors in human preneoplastic and neoplastic gastrointestinal lesions suggests a role in cancer development. In addition to the growth-promoting action of gastrin, recently a role of the cholecystokinin-2/gastrin receptor (CCK2-R) modulating cellular morphology
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Global Trade Item Number

SKUGTIN
A1164-.5MG04061833341926

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