A1164
Azaserine
Hybri-Max™, γ-irradiated, 50x, lyophilized powder, BioXtra, suitable for hybridoma
Synonym(s):
O-Diazoacetyl-L-serine
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About This Item
Empirical Formula (Hill Notation):
C5H7N3O4
CAS Number:
Molecular Weight:
173.13
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
204-061-6
Beilstein/REAXYS Number:
1726602
MDL number:
grade
Hybri-Max™
Quality Segment
sterility
γ-irradiated
product line
BioXtra
form
lyophilized powder
technique(s)
cell culture | hybridoma: suitable
impurities
endotoxin, tested
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
InChI
1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1
InChI key
MZZGOOYMKKIOOX-VKHMYHEASA-N
General description
Chemical structure: amino acid derivatives
Application
For use in hybridoma cell culture applications as a myeloma selection agent. Used to study inhibition of formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.
Biochem/physiol Actions
Azaserine is an antibiotic, generated by Streptomyces fragilis. It is considered as a potential mutation inducing agent. It is known to promote pancreatic cancer and induces adenoma and carcinoma in vivo and in vitro. Azaserine also stimulates kidney and liver tumors in rats.
Preparation Note
Reconstitute contents of vial with 10 mL sterile cell culture medium. Stock solution is sufficient to prepare 500 mL medium. Final working concentration: 5.7 μM azaserine.
Legal Information
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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