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Merck
CN

A1479

Sigma-Aldrich

Angiopoietin-4 human

recombinant, expressed in NSO cells, ≥85% (SDS-PAGE), lyophilized powder

Synonym(s):

ANG-4

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About This Item

MDL number:
MFCD06798420
UNSPSC Code:
51111800

Key Documents

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biological source

human

recombinant

expressed in NSO cells

Assay

≥85% (SDS-PAGE)

form

lyophilized powder

mol wt

apparent mol wt 60-100 kDa by SDS-PAGE (reducing)
calculated mol wt 57 kDa

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

Q9Y264

storage temp.

−20°C

Gene Information

human ... ANGPT4(51378)

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline, pH 6.8, containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to compete with biotinylated recombinant human ANG-2 for binding to immobilized Tie-2/Fc in an ELISA.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

胰岛素激素类产品
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
084K0905

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Spencer B Mamer et al.
Scientific reports, 7(1), 16439-16439 (2017-11-29)
Nearly all studies of angiogenesis have focused on uni-family ligand-receptor binding, e.g., VEGFs bind to VEGF receptors, PDGFs bind to PDGF receptors, etc. The discovery of VEGF-PDGFRs binding challenges this paradigm and calls for investigation of other ligand-receptor binding possibilities.
M Nishimura et al.
FEBS letters, 448(2-3), 254-256 (1999-04-28)
A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human
D M Valenzuela et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(5), 1904-1909 (1999-03-03)
The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium. The angiopoietins include a naturally occurring agonist, angiopoietin-1, as well as a naturally occurring antagonist

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