A1527
Adrenocorticotropic Hormone Fragment 7-38 human
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C167H257N47O46
CAS Number:
Molecular Weight:
3659.11
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥97% (HPLC)
biological source
synthetic (organic)
Quality Level
sterility
non-sterile
assay
≥97% (HPLC)
form
powder
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... POMC(5443)
Application
Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.
Biochem/physiol Actions
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.
Other Notes
ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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C H Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 75(9), 4306-4309 (1978-09-01)
A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity
Min-Jung Kang et al.
Analytical and bioanalytical chemistry, 404(8), 2249-2258 (2012-09-04)
A multireaction monitoring method using high-performance liquid chromatography-tandem mass spectrometry was developed for 12 target peptides for determination of endogenous peptide concentrations in human serum. Chromatographic separation conditions were optimized and recoveries for liquid-liquid extraction, solid-phase extraction (SPE), and ultrafiltration
A Markowska et al.
Cell and tissue research, 272(3), 439-445 (1993-06-01)
Within two weeks, hypophysectomy induced in rats a striking decrease in the level of circulating ACTH (the concentration of which was at the limit of sensitivity of our assay system), coupled with a net reduction in the plasma corticosterone concentration
D H Patterson et al.
Analytical chemistry, 67(21), 3971-3978 (1995-11-01)
The utility of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry for the analysis of C-terminal peptide ladders from carboxypeptidase Y (CPY) digestions is discussed. MALDI analysis of aliquots of an optimized time-dependent CPY digestion of ACTH 7-38 fragment allowed for
R L Shew et al.
The Journal of pharmacology and experimental therapeutics, 230(1), 1-6 (1984-07-01)
Synthetic bovine parathyroid hormone containing the 1-34 NH2 terminal amino acids [bPTH-(1-34)] is capable of inhibiting stimulated uterine contraction. The purpose of the present investigation is to determine whether the inhibitory action of bPTH-(1-34) is a direct action of the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A1527-.5MG | 04061832815992 |
| A1527-250UG | 04061832816012 |
| A1527-1MG | 04061826278130 |
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