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A1757

6-Azauracil

Name: 6-Azauracil
Brand: SIGMA

≥98%, powder

Synonym(s):

6-AU, 1,2,4-Triazine-3,5(2H,4H)-dione, 3,5-Dihydroxy-1,2,4-triazine, 6-Aza-2,4-dihydroxypyrimidine

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About This Item

Empirical Formula (Hill Notation):

C₃H₃N₃O₂

CAS Number:

461-89-2

Molecular Weight:

113.07

NACRES:

NA.51

PubChem Substance ID:

24890584

UNSPSC Code:

41106305

EC Number:

207-318-0

MDL number:

MFCD00006456

Beilstein/REAXYS Number:

116472

Assay:

≥98%

Form:

powder

Solubility:

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green

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Properties

Product Name

6-Azauracil, ≥98%

Quality Segment

100

assay

≥98%

form

powder

mp

274-275 °C (lit.)

solubility

1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow-green

SMILES string

O=C1NN=CC(=O)N1

InChI

1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)

InChI key

SSPYSWLZOPCOLO-UHFFFAOYSA-N

Description

Application

6-Azauracil has been used as a transcriptional inhibitor to study its effects on the deletion of termination and polyadenylation protein (Tpa1) and Mag1 on cell viability. It has also been used as an orotidine-5′-monophosphate decarboxylase (OMPdecase) inhibitor in minimal media for determining the OMPdecase activity.

Biochem/physiol Actions

6-Azauracil (6-AU) is a pyrimidine analog of uracil and exhibits antitumor activity. It inhibits the growth of various microorganisms by depleting intracellular guanosine triphosphate (GTP) and uridine triphosphate (UTP) nucleotide pools.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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