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A1852

Sigma-Aldrich

Adenosine 5′-triphosphate (ATP) disodium salt hydrate

vial of 30 mg

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Synonym(s):
ATP disodium hydrate
Linear Formula:
C10H14N5O13P3Na2 · xH2O
CAS Number:
34369-07-8
Molecular Weight:
551.14 (anhydrous basis)
EC Number:
213-579-1
MDL number:
MFCD00150755
eCl@ss:
32160414
PubChem Substance ID:
24890593
NACRES:
NA.51

biological source

microbial (Corynebacterium sp.)

Quality Level

200

Assay

≥99% (HPLC)

form

powder

packaging

vial of 30 mg

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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General description

Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger CAMP. ATP provides the metabolic energy to drive metabolic pumps.

Application

ATP serves as a coenzyme in a wide array of enzymatic reactions.Adenosine 5′-triphosphate (ATP) disodium salt hydrate is used for tissue preparation and maintenance.
Adenosine 5′-triphosphate (ATP) disodium salt hydrate has been used:
  • in rat hippocampal slice cultures to mimic synaptic signalling
  • in the isolation of plasmid from primary porcine alveolar macrophages (PAMs)
  • as a component of hot reaction kinase buffer for in gel kinase assay

Biochem/physiol Actions

P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Mark D A van Logtestijn et al.
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Park HS, et al.
Journal of Virology, JVI-00022 (2018)
Bio-Protocol
Pizzio GA and Rodriguez PL
Testing, 7(5) (2017)
JuanJuan Duan et al.
Cellular signalling, 58, 44-52 (2019-03-12)
Persistent inflammasome activation contributes to chronic, low grade inflammation. However, it is unclear how the inflammasome activation is sustained after initiation. Here we reported that N4-acetylcytidine (N4A), a nucleoside metabolite, activated microglia and sustained NLRP3 inflammasome activation by inducing HMGB1
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