A2027
L-Arginine-7-amido-4-methylcoumarin hydrochloride
cathepsin H substrate
Synonym(s):
Arginine 4-methyl-7-coumarylamide
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About This Item
Empirical Formula (Hill Notation):
C16H21N5O3
CAS Number:
Molecular Weight:
331.37
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Quality Level
assay
≥97% (TLC)
form
powder
solubility
acetic acid: water (1:1): 50 mg/mL, clear, colorless to light yellow
storage temp.
−20°C
SMILES string
Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@@H](N)CCCNC(N)=N)ccc12
InChI
1S/C16H21N5O3.ClH/c1-9-7-14(22)24-13-8-10(4-5-11(9)13)21-15(23)12(17)3-2-6-20-16(18)19;/h4-5,7-8,12H,2-3,6,17H2,1H3,(H,21,23)(H4,18,19,20);1H/t12-;/m0./s1
InChI key
PFLMUQNBZRXRHD-YDALLXLXSA-N
Application
L-Arginine-7-amido-4-methylcoumarin hydrochloride has been used as a substrate for cathepsin H from rat muscle homogenate and sarcoplasmic extract. It has also been used as a substrate for arginine amino-peptidase from Daphnia homogenates and recombinant aminopeptidase from Toxoplasma gondii.
Biochem/physiol Actions
L-Arginine-7-amido-4-methylcoumarin hydrochloride is a protease substrate. It is a specific substrate for cathepsin H and not for cathepsin L and B.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Product Information Sheet
Wonnop Visessanguan et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 134(3), 477-487 (2003-03-12)
A predominant, heat-activated proteinase in muscle extract of arrowtooth flounder (Atheresthes stomias) was purified to 55-fold by heat treatment, followed by a series of chromatographic separations. The apparent molecular mass of the purified enzyme was 27 kDa by size exclusion
Natália Angelo da Silva Miyaguti et al.
Biomolecules, 9(6) (2019-06-16)
Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich
Emilia M Marijanovic et al.
The Biochemical journal, 477(19), 3819-3832 (2020-09-15)
Toxoplasmosis is a parasitic disease caused by infection with Toxoplasma gondii that currently has few therapeutic options. The M1 aminopeptidase enzymes have been shown to be attractive targets for anti-parasitic agents and/or vaccine candidates, suggesting potential to re-purpose inhibitors between
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2027-5MG | 04061833343692 |
| A2027-25MG | 04061833054413 |