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Merck
CN

A2027

L-Arginine-7-amido-4-methylcoumarin hydrochloride

cathepsin H substrate

Synonym(s):

Arginine 4-methyl-7-coumarylamide

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About This Item

Empirical Formula (Hill Notation):
C16H21N5O3
CAS Number:
Molecular Weight:
331.37
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
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Quality Segment

assay

≥97% (TLC)

form

powder

solubility

acetic acid: water (1:1): 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@@H](N)CCCNC(N)=N)ccc12

InChI

1S/C16H21N5O3.ClH/c1-9-7-14(22)24-13-8-10(4-5-11(9)13)21-15(23)12(17)3-2-6-20-16(18)19;/h4-5,7-8,12H,2-3,6,17H2,1H3,(H,21,23)(H4,18,19,20);1H/t12-;/m0./s1

InChI key

PFLMUQNBZRXRHD-YDALLXLXSA-N

Application

L-Arginine-7-amido-4-methylcoumarin hydrochloride has been used as a substrate for cathepsin H from rat muscle homogenatePMID 31200474 and sarcoplasmic extract.PMID 32426720 It has also been used as a substrate for arginine amino-peptidase from Daphnia homogenatesPMID 31195967 and recombinant aminopeptidase from Toxoplasma gondii.PMID 32926129

Biochem/physiol Actions

L-Arginine-7-amido-4-methylcoumarin hydrochloride is a protease substrate. It is a specific substrate for cathepsin H and not for cathepsin L and B.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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