A2126
Acetyl-β-methylcholine bromide
≥99%
Synonym(s):
Methacholine bromide
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About This Item
Linear Formula:
CH3CO2CH(CH3)CH2N(CH3)3Br
CAS Number:
Molecular Weight:
240.14
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352103
EC Number:
206-372-2
MDL number:
Quality Level
assay
≥99%
form
powder
mp
147-149 °C (lit.)
storage temp.
−20°C
SMILES string
[Br-].CC(C[N+](C)(C)C)OC(C)=O
InChI
1S/C8H18NO2.BrH/c1-7(11-8(2)10)6-9(3,4)5;/h7H,6H2,1-5H3;1H/q+1;/p-1
InChI key
MMVPLEUBMWUYIB-UHFFFAOYSA-M
Gene Information
human ... CHRM3(1131)
Application
Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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David C Hornigold et al.
British journal of pharmacology, 138(7), 1340-1350 (2003-04-25)
1. We have examined possible mechanisms of cross-talk between the G(q/11)-linked M(3) muscarinic acetylcholine (mACh) receptor and the G(i/o)-linked M(2) mACh receptor by stable receptor coexpression in Chinese hamster ovary (CHO) cells. A number of second messenger (cyclic AMP, Ins(1,4,5)P(3))
M Yamada et al.
Nature, 410(6825), 207-212 (2001-03-10)
Members of the muscarinic acetylcholine receptor family (M1-M5) have central roles in the regulation of many fundamental physiological functions. Identifying the specific receptor subtype(s) that mediate the diverse muscarinic actions of acetylcholine is of considerable therapeutic interest, but has proved
John T Fisher et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(6), 711-713 (2004-02-24)
The presence of multiple muscarinic acetylcholine receptor (mAChR) subtypes in the heart and lung, combined with the lack of mAChR subtype-selective ligands, have complicated the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2126-100G | 04061832860817 |