A2327
Adrenomedullin 52 human
≥90% (HPLC), powder
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About This Item
Empirical Formula (Hill Notation):
C264H406N80O77S3
CAS Number:
Molecular Weight:
6028.73
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
General description
Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia.
Application
Adrenomedullin 52 human has been used in tube formation assay in human umbilical vein endothelial cells (HUVECs).
Biochem/physiol Actions
Elicits a potent hypotensive effect; plays a key role in regulating endometrial angiogenesis.
Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
涉药品监管产品
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Novel peptide antagonists of adrenomedullin and calcitonin gene-related peptide receptors: identification, pharmacological characterization, and interactions with position 74 in receptor activity-modifying protein 1/3.
Robinson, SD et al.
Journal of Pharmacology and Experimental Therapeutics, 331(2), 513-521 (2009)
Adrenomedullin in the growth modulation and differentiation of acute myeloid leukemia cells.
Di Liddo R, et al.
International Journal of Oncology, 48(4), 1659-1669 (2016)
A Fedorowski et al.
Journal of internal medicine, 273(4), 359-367 (2013-03-21)
The aim of the study was to investigate the resting levels of novel cardiovascular biomarkers in common types of noncardiac syncope. An observational study was conducted including 255 patients (mean age 60 years, range 15-93; 45% men) with unexplained syncopal
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2327-.1MG | 04061833350003 |