A2394
Acetylcholine perchlorate
Synonym(s):
ACh
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About This Item
Empirical Formula (Hill Notation):
C7H16ClNO6
CAS Number:
Molecular Weight:
245.66
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
213-166-6
MDL number:
Gene Information
human ... CHRM3(1131)
InChI key
SHIQLFRCVFUYEK-UHFFFAOYSA-M
InChI
1S/C7H16NO2.ClHO4/c1-7(9)10-6-5-8(2,3)4;2-1(3,4)5/h5-6H2,1-4H3;(H,2,3,4,5)/q+1;/p-1
SMILES string
[O-]Cl(=O)(=O)=O.CC(=O)OCC[N+](C)(C)C
assay
≥98.0% (TLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
Application
Acetylcholine is an endogenous neurotransmitter at cholinergic synapses that amplifies action potential of the sarcolemma thereby inducing muscle contractions.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Aswin Verhoeven et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 168(2), 314-326 (2004-05-14)
It is demonstrated that internuclear distances can be evaluated from rotational-resonance (RR) experiments in uniformly (13)C-labelled compounds. The errors in the obtained distances are less than 10% without the need to know any parameters of the spin system except the
Vincent Laurent et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1358-1369 (2014-01-24)
Decision-making depends on the ability to extract predictive information from the environment to guide future actions. Outcome-specific Pavlovian-instrumental transfer (PIT) provides an animal model of this process in which a stimulus predicting a particular outcome biases choice toward actions earning
Jeppe A Olsen et al.
The Journal of biological chemistry, 288(50), 35997-36006 (2013-10-31)
Positive allosteric modulators (PAMs) of α4β2 nicotinic acetylcholine receptors have the potential to improve cognitive function and alleviate pain. However, only a few selective PAMs of α4β2 receptors have been described limiting both pharmacological understanding and drug-discovery efforts. Here, we
Carolina Wedemeyer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(39), 15477-15487 (2013-09-27)
The synapse between olivocochlear (OC) neurons and cochlear mechanosensory hair cells is cholinergic, fast, and inhibitory. The inhibitory sign of this cholinergic synapse is accounted for by the activation of Ca(2+)-permeable postsynaptic α9α10 nicotinic receptors coupled to the opening of
Sulan Luo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1842-1853 (2014-01-09)
This study was performed to discover and characterize the first potent α3β2-subtype-selective nicotinic acetylcholine receptor (nAChR) ligand. A novel α4/7-conotoxin, α-CTxLvIA, was cloned from Conus lividus. Its pharmacological profile at Xenopus laevis oocyte-expressed rat nAChR subtypes was determined by 2-electrode
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