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Merck
CN

A244

trans-Azetidine-2,4-dicarboxylic acid

solid

Synonym(s):

tADA

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About This Item

Empirical Formula (Hill Notation):
C5H7NO4
CAS Number:
161596-62-9
Molecular Weight:
145.11
UNSPSC Code:
12352200
PubChem Substance ID:
24277956
MDL number:
MFCD00236469

Key Documents

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InChI

1S/C5H7NO4/c7-4(8)2-1-3(6-2)5(9)10/h2-3,6H,1H2,(H,7,8)(H,9,10)/t2-,3-/m1/s1

SMILES string

OC(=O)[C@H]1C[C@@H](N1)C(O)=O

InChI key

JMVIGOFRIJJUAW-PWNYCUMCSA-N

form

solid

color

white

solubility

H2O: 5.7 mg/mL

Gene Information

human ... GRM1(2911), GRM5(2915)
rat ... Grm1(24414), Grm2(24415)

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Biochem/physiol Actions

mGluR1 and mGluR5 metabotropic glutamate receptor agonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
107H4620
107H46204

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G Riedel et al.
Neuropharmacology, 34(5), 559-561 (1995-05-01)
As demonstrated recently, mGluRs are involved in some forms of learning. We thus investigated the effect of tADA (trans-azetidine-2,4-dicarboxylic acid) applied intracerebroventricularly prior to learning a spatial alternation paradigm. Compared to controls, tADA treated animals were amnesic when tested for
M Favaron et al.
Neuroreport, 4(7), 967-970 (1993-07-01)
The expression of metabotropic glutamate receptors (mGluRs) in primary cultures of cerebellar granule neurones can be: (i) modulated by the degree of depolarization during the culture period, rendering neurones differently sensitive to agonist-stimulated inositol phosphate (IP) hydrolysis; (ii) down-regulated by
R E Brown et al.
Neuroscience letters, 202(1-2), 73-76 (1995-12-29)
The possibility that activation of class I (phospholipase C-coupled) metabotropic glutamate receptors (mGluRs) can facilitate the induction of long-term potentiation (LTP) was investigated in the dentate gyrus of rat hippocampal slices. In the presence of picrotoxin, a weak tetanus led

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