Skip to Content
Merck
CN

A2559

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

≥97% (HPLC), powder

Synonym(s):

Ac-DEVD-pNA

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C26H34N6O13
CAS Number:
189950-66-1
Molecular Weight:
638.58
NACRES:
NA.32
PubChem Substance ID:
24890668
UNSPSC Code:
12352209
MDL number:
MFCD00792707
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide, ≥97% (HPLC), powder

InChI key

GGXRLUDNGFFUKI-ORGXJRBJSA-N

SMILES string

CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1

assay

≥97% (HPLC)

form

powder

color

white

storage temp.

−20°C

Quality Level

100

Gene Information

human ... CASP3(836)

Application

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.

Biochem/physiol Actions

Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000469536
0000469536
0000266365
0000266365
SLCQ3582

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hui-Fang Jin et al.
Frontiers in cell and developmental biology, 8, 555937-555937 (2020-10-20)
MicroRNAs (miRNAs) are dysregulated in the context of many cancer types, making them potentially ideal diagnostic or therapeutic targets in patients in which they are aberrantly expressed. In the present study, we found miR-7 to be downregulated in gastric cancer
Human cytomegalovirus immediate early protein 2 enhances myocardin-mediated survival of rat aortic smooth muscle cells.
Liao XH, et al.
Virus Research, 192(2), 85-91 (2014)
Xiangyu Wang et al.
Frontiers in cellular and infection microbiology, 7, 410-410 (2017-10-07)
Enterohemorrhagic
Nrf2 protects against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis.
Lu H, et al.
Toxicology and Applied Pharmacology, 256(2), 122-135 (2011)
Juan Yao et al.
Free radical biology & medicine, 152, 659-667 (2020-01-14)
The alteration of redox homeostasis is a hallmark of cancer cells. As a critical player in regulating cellular redox signaling, thioredoxin reductase (TrxR) enzymes are increasingly recognized as attractive targets for anticancer drug development. We reported herein the natural product
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service