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A2559

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide

Name: N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide
Brand: SIGMA

≥97% (HPLC), powder

Synonym(s):

Ac-DEVD-pNA

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₃₄N₆O₁₃

CAS Number:

189950-66-1

Molecular Weight:

638.58

NACRES:

NA.32

PubChem Substance ID:

24890668

UNSPSC Code:

12352209

MDL number:

MFCD00792707

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1

InChI key

GGXRLUDNGFFUKI-ORGXJRBJSA-N

Gene Information

human ... CASP3(836)

Application

N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.

Biochem/physiol Actions

Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number

0000548099

0000469536

0000266365

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Down-Regulation of miR-7 in Gastric Cancer Is Associated With Elevated LDH-A Expression and Chemoresistance to Cisplatin.

Hui-Fang Jin et al.

Frontiers in cell and developmental biology, 8, 555937-555937 (2020-10-20)

MicroRNAs (miRNAs) are dysregulated in the context of many cancer types, making them potentially ideal diagnostic or therapeutic targets in patients in which they are aberrantly expressed. In the present study, we found miR-7 to be downregulated in gastric cancer

Nrf2 protects against 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis.

Lu H, et al.

Toxicology and Applied Pharmacology, 256(2), 122-135 (2011)

High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway.

Ouyang Chen et al.

Scientific reports, 7(1), 14871-14871 (2017-11-03)

The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). C57BL/6 mice were randomly divided into the following groups: sham, I/R, I/R + HCH, I/R + HCH + LY294002 (PI3K inhibitor), I/R + HCH + wortmannin (PI3K inhibitor), I/R + LY294002, and I/R + wortmannin. After 45 min of ischemia, HCH

Detection of Superoxide Alterations Induced by 5-Fluorouracil on HeLa Cells with a Cell-Based Biosensor.

Sophia Mavrikou et al.

Biosensors, 9(4) (2019-10-19)

In vitro cell culture monitoring can be used as an indicator of cellular oxidative stress for the assessment of different chemotherapy agents. A cell-based bioelectric biosensor was used to detect alterations in superoxide levels in the culture medium of HeLa

Sanguinarine as a new chemical entity of thioredoxin reductase inhibitor to elicit oxidative stress and promote tumor cell apoptosis.

Juan Yao et al.

Free radical biology & medicine, 152, 659-667 (2020-01-14)

The alteration of redox homeostasis is a hallmark of cancer cells. As a critical player in regulating cellular redox signaling, thioredoxin reductase (TrxR) enzymes are increasingly recognized as attractive targets for anticancer drug development. We reported herein the natural product

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Global Trade Item Number

SKU	GTIN
A2559-1MG	04061823596954
A2559-15MG	04061832776033
A2559-5MG	04061833352236

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