A2562
Angiotensinogen from human plasma
≥80% (SDS-PAGE)
Synonym(s):
Hypertensinogen, Renin substrate
Related Categories
Biochem/physiol Actions
Angiotensinogen (renin substrate), a component of the rennin-angiotensin system, is a precursor protein to a family of blood pressure and hormone release regulating peptides known as the angiotensins.
Packaging
Package size based on protein content.
Physical form
Lyophilized powder containing sodium phosphate buffer, pH 7.
Analysis Note
Protein determined by A1%/280
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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R T Radulescu
Bioscience trends, 6(6), 340-341 (2013-01-23)
Hypertension ranks among the most important disease challenges on a global scale. Here, a novel hypothesis is presented which implicates angiotensinogen, i.e. the precursor protein for the hypertensive peptide angiotensin II, as a key culprit in the pathogenesis of hypertension.
O von Bohlen und Halbach
Current protein & peptide science, 6(4), 355-371 (2005-08-17)
The brain renin-angiotensin system enables the formation of different biological active forms of angiotensins within the brain. All enzymes and peptides necessary for the biosynthesis of these angiotensins have been recognized within the central nervous system. Since there are considerable
John W Wright et al.
Progress in neurobiology, 95(1), 49-67 (2011-07-23)
The classic renin-angiotensin system (RAS) is described as a circulating hormone system focused on cardiovascular and body water regulation, with angiotensin II as its major effector. Detlef Ganten's discovery some years ago of an independent local brain RAS composed of
D A Tewksbury
Federation proceedings, 42(10), 2724-2728 (1983-07-01)
Human angiotensinogen has been purified from outdated blood bank plasma. The purified angiotensinogen has a specific angiotensin I (Ang I) content of 20.7 micrograms Ang I/mg protein and contains only one amino-terminal amino acid, aspartic acid. However, it exhibits two
Weijian Shao et al.
American journal of physiology. Renal physiology, 304(5), F505-F514 (2013-01-11)
In angiotensin II (ANG II) infusion hypertension, there is an augmentation of intratubular angiotensinogen (AGT) and ANG II leading to increased urinary AGT and ANG II excretion rates associated with tissue injury. However, the changes in urinary AGT and ANG
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