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Merck
CN

A2628

L-Alanine β-naphthylamide

protease substrate

Synonym(s):

L-Alanine 2-naphthylamide

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About This Item

Empirical Formula (Hill Notation):
C13H14N2O
CAS Number:
720-82-1
Molecular Weight:
214.26
PubChem Substance ID:
24890677
eCl@ss:
32160406
UNSPSC Code:
12352204
NACRES:
NA.83
EC Number:
211-956-5
MDL number:
MFCD00064969

Key Documents

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Product Name

L-Alanine β-naphthylamide, protease substrate

InChI key

RQHPADKWNYTHOH-VIFPVBQESA-N

InChI

1S/C13H14N2O/c1-9(14)13(16)15-12-7-6-10-4-2-3-5-11(10)8-12/h2-9H,14H2,1H3,(H,15,16)/t9-/m0/s1

SMILES string

C[C@H](N)C(=O)Nc1ccc2ccccc2c1

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear to slightly hazy

storage temp.

2-8°C

Quality Level

200

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Application

L-Alanine Ǧ-naphthylamide has been used to determine the activity of alanine aminopeptidase (AAP) in blood samples. It may be used as a fluorescent substrate to assay neutral aminopeptidase (APN) activity in cultured human and mouse chondrocytes.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP0061
BCCN3221
BCCM0893
BCCL2076
BCCJ7819

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Simone Cristina Yamasaki et al.
Regulatory peptides, 173(1-3), 47-54 (2011-10-11)
This study evaluated the hypothesis that neutral (APN) and dipeptidyl-IV (DPPIV) aminopeptidase activity levels would be critical for the susceptibility to arthritis in collagen-induced model (CIA). The macroscopic signs of arthritis in CIA rats were checked and peripheral blood, synovial
Anna Bizoń et al.
Environmental toxicology and pharmacology, 53, 74-80 (2017-05-16)
The effect of tobacco smoke on lipid peroxidation, the lipid profile and membrane-bound enzymatic activity in the first trimester of pregnancy was investigated. In the plasma of women with active exposure to tobacco smoke, we have found increased lipid peroxidation
Meriam Nefla et al.
Journal of cell science, 128(17), 3250-3262 (2015-07-26)
Osteoarthritis is a whole-joint disease characterized by the progressive destruction of articular cartilage involving abnormal communication between subchondral bone and cartilage. Our team previously identified 14-3-3ε protein as a subchondral bone soluble mediator altering cartilage homeostasis. The aim of this
S K Nag Das et al.
The Italian journal of biochemistry, 37(3), 148-164 (1988-05-01)
A 50.4-fold purification of aminopeptidase is achieved by alcohol precipitation, DEAE-cellulose, CM-cellulose and finally Sephadex G-200 chromatography. On polyacrylamide gel electrophoresis of the purified enzyme after molecular sieving on Sephadex G-200, only one band was obtained, suggesting that the enzyme
W Sidorowicz et al.
Clinica chimica acta; international journal of clinical chemistry, 107(3), 245-256 (1980-11-06)
Human pancreas, kidney, and liver alanine aminopeptidases have similar if not identical antigenic determinants even though these three isoenzymes have distinctly different electrophoretic mobilities. Single precipitin lines without spur formation were obtained for all three enzymes with antisera obtained from
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