Key Documents

View All Documentation

A2647

Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate

Name: Adenosine 5&#8242;-(&#946;,&#947;-imido)triphosphate lithium salt hydrate
Brand: SIGMA

≥93% (HPLC), natural (organic), powder

Synonym(s):

β,γ-Imidoadenosine 5′-triphosphate lithium salt hydrate, AMP-PNP, ATP[β,γ-NH], Adenylyl imidodiphosphate lithium salt hydrate, App(NH)p

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₇N₆O₁₂P₃ · xLi⁺ · yH₂O

CAS Number:

25612-73-1

Molecular Weight:

506.20 (free acid basis)

MDL number:

MFCD03424105

UNSPSC Code:

41106305

PubChem Substance ID:

24890685

NACRES:

NA.51

Beilstein/REAXYS Number:

6047109

Assay:

≥93% (HPLC)

Biological source:

natural (organic)

Form:

powder

Solubility:

H₂O: 50 mg/mL

Storage temp.:

−20°C

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate, ≥93% (HPLC), powder

biological source

natural (organic)

Quality Level

200

assay

≥93% (HPLC)

form

powder

color

white

solubility

H₂O: 50 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1

InChI key

PVKSNHVPLWYQGJ-KQYNXXCUSA-N

Description

Application

Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li⁺, Na⁺, K⁺, NH₄⁺, Rb⁺ and Cs⁺ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide.

Biochem/physiol Actions

A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels.

Preparation Note

A 10 mg/mL stock solution may be made, aliquoted and stored at -70 °C for up to 3 months.

Disclaimer

AMP-PNP is very unstable in acidic conditions; rapidly hydrolyzes to the phosphoramidate and inorganic phosphate.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000504692

0000504691

0000504689