Anti-α₁ Adrenergic Receptor antibody produced in rabbit

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three α1AR subtypes (α1A/D, α1B, and α1C), three α2ARs (α2A, α2B, and α2C), and three βAR subtypes (β1, β2, and β3). Adrenergic receptors participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.

Adrenergic receptors are a G-protien coupled receptors that exist in two forms, α or β. Ligands for adrenergic receptors are catecholamines that induce a sympathetic response in animal cells.

Rabbit polyclonal Anti-α1 Adrenergic Receptor antibody is human α1 adrenergic receptor subtype-specific and cross-reacts with rat and mouse α1 adrenergic receptor in immunoblotting. It detects α1 adrenergic receptor in mouse kidney membrane preparations by immunoblotting and stains plasma membrane of mouse kidney distal tubule cells in immunofluorescence.

A270 is produced by immunizing New Zealand white rabbits with a synthetic peptide corresponding to aa residues 339-349 of human alpha 1a adrenergic receptor. This sequence is 100% conserved within the 3rd intracellular loop of all alpha1 adrenergic receptors. Peptide sequence: K₃₃₉-F-S-R-E-K-K-A-A-K-T₃₄₉

Rabbit polyclonal Anti-α1 Adrenergic Receptor antibody is used for the localization and detection of the α1 adrenergic receptor (~ 60 kDa). It can be used in immunoblotting and immunofluorescence techniques.

Solution in phosphate buffered saline containing 1 mg/ml BSA and 0.05% sodium azide.

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