A2862
Astilbin from Engelhardtia roxburghiana
≥98%
Synonym(s):
Astilbin, Dihydroquercetin 3-rhamnoside, Taxifolin 3-rhamnoside
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About This Item
Empirical Formula (Hill Notation):
C21H22O11
CAS Number:
Molecular Weight:
450.39
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
assay
≥98%
form
powder
solubility
H2O: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(O)=C(O)C=C3)[C@H]1O[C@@]4([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4
InChI
1S/C21H22O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-26,28-29H,1H3/t7-,15-,17+,18+,19-,20+,21-/m0/s1
InChI key
ZROGCCBNZBKLEL-MFSALPCASA-N
General description
Astilbin belongs to the class of dihydroflavanol compounds and is the chief biologically active component of Rhizoma Smilacis Glabrae (RSG) extract. RSG is obtained from the dried rhizome of Smilax Glabra Roxb.
Application
Astilbin from Engelhardtia roxburghiana, a flavonoid phytochemical with antibacterial activity, may be used to study its pharmacology and the effects of its antiproliferative activities versus a variety of cell types.
Biochem/physiol Actions
Astilbin exerts various biological activities such as anti-oxidative, anti-bacterial, and inhibition of contact hypersensitivity. Also, it shows insecticidal, anti-oedematogenic, antinociceptive and antidepressant properties. It has an inhibitory effect on the aldose reductase enzyme, the accumulation of sorbitol, and a protective effect on the liver. Astilbin is helpful against autoimmune diseases such as rheumatoid arthritis due to its ability to reduce matrix metalloproteinase (MMP) activity and Nitric oxide production in T lymphocytes.
Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations. Immunosuppresive. Antiproliferative.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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O Mezghrani et al.
Die Pharmazie, 66(10), 754-760 (2011-10-27)
The main purpose of this research work was to design an optimized self micro-emulsifying drug delivery system (SMEDDS) to enhance the bioavailability of the poor water soluble drug, astilbin. The solubility of astilbin was evaluated in various vehicles. Pseudoternary phase
Xi-Cheng He et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(23), 3595-3598 (2013-03-13)
Astilbin in 28 Smilax glabra (red and white cross-section) from different sources was determined by HPLC. Pharmacodynamics and component of S. glabra was investigated through inflammation experiment (penetration type). The analysis was performed on a Hypersil ODS2 column (4.6 mm
Jingqun Huang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(9), 1943-1947 (2011-05-24)
Flavonoids are widely found in plants and many of them possess biological and pharmacological activities. In the present study, we assessed the effects of the flavonoids Genistein, Apigenin, Quercetin, Rutin and Astilbin on xanthine oxidase (XO) activities in vitro, and
Y Cai et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52(8), 334-340 (2003-09-25)
To examine the therapeutic effects of astilbin, a flavanoid isolated from Rhizoma Smilacis Glabrae, on arthritis and to compare it with cyclosporine A (CsA). Type II collagen-induced arthritis in mice and its in vitro assays for proliferation, matrix metalloproteinase (MMP)
Xiao-dan Wang et al.
International journal of pharmaceutics, 378(1-2), 1-8 (2009-05-26)
This study was designed to understand the transport profiles of astilbin and taxifolin in Caco-2 cell model and their effects on the function and expression of P-glycoprotein. The transport studies were examined using Caco-2 cells cultured on Transwell inserts. Their
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2862-10MG | 04061833359846 |
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