A2987
Atractylenolide III
≥98% (HPLC)
Synonym(s):
8β-Hydroxyasterolide, Codonolactone
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About This Item
Empirical Formula (Hill Notation):
C15H20O3
CAS Number:
Molecular Weight:
248.32
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C15H20O3/c1-9-5-4-6-14(3)8-15(17)12(7-11(9)14)10(2)13(16)18-15/h11,17H,1,4-8H2,2-3H3/t11-,14+,15-/m0/s1
SMILES string
CC1=C2C[C@H]3C(=C)CCC[C@]3(C)C[C@]2(O)OC1=O
InChI key
FBMORZZOJSDNRQ-GLQYFDAESA-N
biological source
Atractylodes macrocephala Koidz.
assay
≥98% (HPLC)
form
powder or crystals
color
white to off-white
solubility
methanol: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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General description
Atractylenolide III is a biologically active sesquiterpene compound, extracted from the roots of Atractylodes macrocephala Koidzumi.
Application
Atractylenolide III has been used to examine its effects on the energy metabolism in the skeletal muscles of mouse.
Atractylenolide III, a sesquiterpenoid, is a phytochemical that may be used to study its anti-inflammatory and anti-angiogenesis activities. Atractylenolide III may be used and studied as an inhibitor of aromatases and inducer of apoptosis. Atractylenolide III may be used to study its sonic hedgehog pathway dependent mechanism of action as an inducer of chondrogenic differentiation. Atractylenolide III may be used as a reference material in assays to detect its presence in plant root extracts and biological milieu such as plasma.
Biochem/physiol Actions
Atractylenolide III has been shown to possess anti-inflammatory effects and also offers gastroprotection. It also shows acaricidal properties and hence has the potential to be used as an agent for the control of dust mites. Atractylenolide III is capable of regulating the secretion and expression of Interleukin-6, thereby mediating the immune response caused by mast cells.
Atractylenolide III possesses anti-inflammatory and anticancer properties.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hyun-Kyung Kim et al.
Journal of agricultural and food chemistry, 55(15), 6027-6031 (2007-06-28)
The acaricidal activity of materials derived from rhizome of Atractylodes ovata (Atractylodes macrocephala) toward adult Dermatophagoides farinae and Dermatophagoides pteronyssinus was examined using fabric-circle residual contact and vapor-phase toxicity bioassays. Results were compared with those of the currently used acaricides:
Yue Qiu et al.
Evidence-based complementary and alternative medicine : eCAM, 2019, 1392020-1392020 (2020-01-18)
Gastroesophageal reflux disease (GERDs) is a common chronic digestive system disease, in which the symptoms of reflux esophagitis (RE) seriously affect the quality of life. We aimed to study the therapeutic effect of Zhujie Hewei granules (ZHG) on reflux esophagitis
Xican Li et al.
Biological & pharmaceutical bulletin, 35(8), 1328-1335 (2012-08-07)
Molecules that enhance chondrogenic differentiation in mesenchymal stem cells (MSCs) were identified and isolated using an in vitro Gli reporter gene assay in MSCs incorporating a Sonic Hedgehog (Shh) target. Atractylenolide III, which promoted Gli1-mediated transcriptional activity, was isolated from
Seung-Hyun Jeong et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1126-1127, 121743-121743 (2019-08-12)
The purpose of this study was to develop a method for simultaneous analysis of fourteen major active components in Gumiganghwal-tang tablet widely prescribed for cold related diseases using UPLC-ESI-MS/MS. Twelve of these 14 components were separated using 0.1% formic acid
Yuanyuan Fu et al.
Journal of pharmaceutical and biomedical analysis, 174, 595-607 (2019-07-02)
Banxia-Baizhu-Tianma decoction (BBTD) is a compound formulae of traditional Chinese medicine (TCM), which has been clinically used for treatments of neural vertigo, hypertension and epilepsy with a long history. In this study, with an ultra-fast liquid chromatography coupled with quadrupole
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