Key Documents

View All Documentation

A3085

5-(N-Ethyl-N-isopropyl)amiloride

Name: 5-(N-Ethyl-N-isopropyl)amiloride
Brand: SIGMA

≥98% (TLC), powder, Na⁺/H⁺ antiport inhibitor

Synonym(s):

EIPA

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₈ClN₇O

CAS Number:

1154-25-2

Molecular Weight:

299.76

UNSPSC Code:

12352200

PubChem Substance ID:

24278223

NACRES:

NA.77

MDL number:

MFCD00151710

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

5-(N-Ethyl-N-isopropyl)amiloride,

biological source

synthetic

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

202-205 °C (lit.)

solubility

methanol: 9.80-10.20 mg/mL, clear, light yellow to yellow

storage temp.

2-8°C

SMILES string

CCN(C(C)C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N

InChI

1S/C11H18ClN7O/c1-4-19(5(2)3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)

InChI key

QDERNBXNXJCIQK-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784), Slc9a4(24785)

Related Categories

Bioactive Small Molecules

Application

5-(N-Ethyl-N-isopropyl)amiloride has been used:

as a supplement in endothelial cell growth medium to incubate human lung microvascular endothelial cell
in Pluronic F-127 stock solution for Drosophila larval live-imaging
in choline chloride solution as an experimental perfusate, to study the effect of Na⁺/H⁺ inhibition on jejunal loop perfusion in vivo

Biochem/physiol Actions

Selective blocker of Na⁺/H⁺ antiport

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000541715

0000486013

0000453948

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The heparin-binding domain of HB-EGF as an efficient cell-penetrating peptide for drug delivery.

Zhao Luo et al.

Journal of peptide science : an official publication of the European Peptide Society, 22(11-12), 689-699 (2016-10-16)

Cell-penetrating peptides (CPPs) have been shown to be potential drug carriers for cancer therapy. The inherently low immunogenicity and cytotoxicity of human-derived CPPs make them more suitable for intracellular drug delivery compared to other delivery vehicles. In this work, the

Na+/H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals

Rossano AJ, et al.

The Journal of Physiology, 595(3), 805-824 (2017)

Transient Nutrient Deprivation Promotes Macropinocytosis-Dependent Intracellular Bacterial Community Development.

Rachael L Hardison et al.

mSphere, 3(5) (2018-09-14)

Nutrient limitation restricts bacterial growth in privileged sites such as the middle ear. Transient heme-iron restriction of nontypeable Haemophilus influenzae (NTHI), the major causative agent of chronic and recurrent otitis media (OM), promotes new and diverse phenotypes that can influence

An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat

Lucas ML and Morrison JD

Physiological Reports, 3(5) (2015)

Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells.

Dipali Patel et al.

Scientific reports, 7(1), 12886-12886 (2017-10-12)

Mammalian mitochondria can be transferred between cells both in culture and in vivo. There is evidence that isolated mitochondria enter cells by endocytosis, but the mechanism has not been fully characterised. We investigated the entry mechanism of isolated mitochondria into

View All Related Papers

Global Trade Item Number

SKU	GTIN
A3085-25MG	04061833360286
A3085-100MG	04061832569055

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service