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A3355

ATC0175

Name: ATC0175
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

N-(cis-4-{[4-(Dimethylamino)quinazolin-2-yl]amino}cyclohexyl)-3,4-difluorobenzamide HCl

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₆ClF₂N₅O

CAS Number:

510733-97-8

Molecular Weight:

461.94

NACRES:

NA.77

PubChem Substance ID:

24724389

UNSPSC Code:

51111800

MDL number:

MFCD08276913

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 5 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)c1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)c3ccc(F)c(F)c3)nc4ccccc14

InChI

1S/C23H25F2N5O.ClH/c1-30(2)21-17-5-3-4-6-20(17)28-23(29-21)27-16-10-8-15(9-11-16)26-22(31)14-7-12-18(24)19(25)13-14;/h3-7,12-13,15-16H,8-11H2,1-2H3,(H,26,31)(H,27,28,29);1H/t15-,16+;

InChI key

HUUPKFUYSQNNLO-FAESNJTISA-N

Biochem/physiol Actions

ATC0175 is a non-peptide, orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist.

Non-peptide, orally active melanin-concentrating hormone receptor 1 (MCHR1) antagonist.

Features and Benefits

This compound is featured on the Melanin-Concentrating Hormone Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335,H413

pcodes

P273 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

016K46171

016K4617

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Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists.

Shigeyuki Chaki et al.

The Journal of pharmacology and experimental therapeutics, 313(2), 831-839 (2005-01-29)

Melanin-concentrating hormone (MCH) is a cyclic peptide produced in the lateral hypothalamus. It has been implicated in a number of physiological processes including feeding behavior, energy balance, and the regulation of emotional states. Here, we report in vitro and in

Global Trade Item Number

SKU	GTIN
A3355-10MG	04061833030578

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