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A3846

AL-8810

Name: AL-8810
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

(5Z, 13E)-(9S,11S,15R)-9,15,Dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20,pentanor-5,13-prostadienoic acid, [1R-[1α(Z),2β(1E,3S*),3β,5α]]-7-[3-Fluoro-5-hydroxy-2-[3-hydroxy-4-[2-(2,3-dihydro-1H-indenyl)]-1-butenyl]cyclolpentyl]-5-heptenoic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₁FO₄

CAS Number:

246246-19-5

Molecular Weight:

402.50

NACRES:

NA.77

PubChem Substance ID:

24278225

UNSPSC Code:

51111800

MDL number:

MFCD04039992

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: soluble 10 mg/mL, ethanol: soluble

storage temp.

2-8°C

SMILES string

O[C@H]1C[C@H](F)[C@H](\C=C\[C@H](O)C2Cc3ccccc3C2)[C@H]1C\C=C/CCCC(O)=O

InChI

1S/C24H31FO4/c25-21-15-23(27)20(9-3-1-2-4-10-24(28)29)19(21)11-12-22(26)18-13-16-7-5-6-8-17(16)14-18/h1,3,5-8,11-12,18-23,26-27H,2,4,9-10,13-15H2,(H,28,29)/b3-1-,12-11+/t19-,20-,21+,22+,23+/m1/s1

InChI key

WTYSXBKKVNOOIX-JTGCGUAKSA-N

Gene Information

human ... PTGFR(5737)

Biochem/physiol Actions

AL-8810 is a novel prostaglandin F_2α analog; selective FP prostanoid receptor antagonist.

Legal Information

Sold under license from Alcon.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction.

Dedmer Schaafsma et al.

Respiratory research, 6, 85-85 (2005-07-29)

In addition to their proliferative and differentiating effects, several growth factors are capable of inducing a sustained airway smooth muscle (ASM) contraction. These contractile effects were previously found to be dependent on Rho-kinase and have also been associated with the

Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential.

Evanthia Nikolopoulou et al.

Journal of lipid research, 55(12), 2479-2490 (2014-10-18)

Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation. AA caused the upregulation of fatty acid

Global Trade Item Number

SKU	GTIN
A3846-5MG	04061832784274

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