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A3940

1-Aminobenzotriazole

Name: 1-Aminobenzotriazole
Brand: SIGMA

≥98% (TLC), powder, cytochrome P450 inhibitor

Greener Alternative

Synonym(s):

1-Benzotriazolamine, ABT

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About This Item

Linear Formula:

H₂NC₆H₄N₃

CAS Number:

1614-12-6

Molecular Weight:

134.14

NACRES:

NA.77

PubChem Substance ID:

24278226

UNSPSC Code:

12352200

MDL number:

MFCD00132902

Beilstein/REAXYS Number:

607843

Assay:

≥98% (TLC)

Form:

powder

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Properties

Product Name

1-Aminobenzotriazole,

assay

≥98% (TLC)

Quality Segment

200

form

powder

greener alternative product score

old score: 93
new score: 46
Find out more about DOZN™ Scoring

greener alternative product characteristics

Waste Prevention
Safer Solvents and Auxiliaries
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

81-84 °C (lit.)

solubility

ethanol: 49-51 mg/mL, clear, pale yellow to yellow

greener alternative category

, Re-engineered

SMILES string

Nn1nnc2ccccc12

InChI

1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2

InChI key

JCXKHYLLVKZPKE-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Application

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H₂O₂-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Biochem/physiol Actions

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

Suicide inhibitor of cytochrome P450 and chloroperoxidase.

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)