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A4562

5-(N,N-Dimethyl)amiloride hydrochloride

Name: 5-(<I>N</I>,<I>N</I>-Dimethyl)amiloride hydrochloride
Brand: SIGMA

cAMP-dependent protein kinase inhibitor, powder

Synonym(s):

3-Amino-N-(aminoiminoethyl)-5-(dimethylamino)-6-chloropyrazinecarboxamide hydrochloride, DMA

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₂ClN₇O · HCl

CAS Number:

1214-79-5

Molecular Weight:

294.14

UNSPSC Code:

12352200

PubChem Substance ID:

24278216

NACRES:

NA.77

MDL number:

MFCD00069207

Form:

powder

Quality level:

200

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Product Name

5-(N,N-Dimethyl)amiloride hydrochloride,

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

Cl.CN(C)c1nc(N)c(nc1Cl)C(=O)\N=C(\N)N

InChI

1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H

InChI key

IIUPTHVVXMBJMQ-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a2(24783), Slc9a3(24784)

Related Categories

Bioactive Small Molecules

Application

5-(N,N-Dimethyl)amiloride hydrochloride is a selective blocker of Na²/H⁺ antiport. 5-(N,N-Dimethyl)amiloride hydrochloride has been investigated for its ability to reduce inflammatory pain.

Biochem/physiol Actions

Selective blocker of Na⁺/H⁺ antiport; IC₅₀ = 6.9 μM.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Global Trade Item Number

SKU	GTIN
A4562-100MG	04061832569086
A4562-25MG	04061833374672

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