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Merck
CN

A4727

Sigma-Aldrich

Antisauvagine-30 trifluoroacetate salt

Synonym(s):

Anti-SVG-30, [D-Phe11,His12]-Sauvagine fragment 11-40 trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C161H274N48O46S
Molecular Weight:
3650.26
MDL number:
MFCD04974485
UNSPSC Code:
12352200
NACRES:
NA.32

Key Documents

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form

powder

Quality Level

200

storage temp.

−20°C

SMILES string

FC(F)(F)C(=O)O.S(CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](N)Cc2ccccc2)Cc1nc[nH]c1)CC(C)C)CC(C)C)CCCNC(=N)N)CCCCN)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@H](CC)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N

InChI

1S/C161H275N49O45S.C2HF3O2/c1-21-84(14)126(130(173)226)207-159(255)129(89(19)211)210-156(252)115(76-125(224)225)206-152(248)111(71-83(12)13)203-150(246)109(69-81(8)9)202-149(245)108(68-80(6)7)200-140(236)98(44-36-65-180-161(176)177)189-154(250)114(75-121(

InChI key

MQNGXZGVAKCDNG-NDMSIQOJSA-N

Gene Information

human ... CRHR2(1395)
mouse ... CRHR2(12922)
rat ... CRHR2(64680)

Amino Acid Sequence

Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2

Biochem/physiol Actions

High-affinity antagonist for Corticotropin-releasing factor (CRF) receptor type 2 (CRF(2)).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
SLBZ5392
SLBP9625V
SLBP1314V
SLBL2897V
080M1732

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Nina C Donner et al.
Psychoneuroendocrinology, 63, 178-190 (2015-10-12)
Anxiety and affective disorders are often associated with hypercortisolism and dysfunctional serotonergic systems, including increased expression of TPH2, the gene encoding the rate-limiting enzyme of neuronal serotonin synthesis. We previously reported that chronic glucocorticoid exposure is anxiogenic and increases rat

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