A5330
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
≥99% (TLC), powder
Synonym(s):
L-732,138
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About This Item
Empirical Formula (Hill Notation):
C22H18F6N2O3
CAS Number:
Molecular Weight:
472.38
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥99% (TLC)
form
powder
mp
147-148 °C (lit.)
storage temp.
−20°C
SMILES string
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc3cc(cc(c3)C(F)(F)F)C(F)(F)F
InChI
1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
InChI key
BYYQYXVAWXAYQC-IBGZPJMESA-N
Gene Information
human ... TACR1(6869)
Biochem/physiol Actions
Competitive substance P receptor antagonist.
Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC50 for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Takenori Onaga et al.
Regulatory peptides, 173(1-3), 64-73 (2011-10-06)
The present study investigated a role of tachykinins (TK) and neurokinin (NK) receptors (NK-R) in the non-cholinergic regulation of omasal contractions in sheep. Semiquantitative reverse transcription (RT)-PCR revealed that both preprotachykinin (PPT)-A and PPT-B mRNA were distributed in the omasal
Ammar Boudaka et al.
European journal of pharmacology, 556(1-3), 157-165 (2006-12-13)
Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, has been suggested to mediate the inhibitory effect of capsaicin on vagally mediated striated muscle contractions in the
Ming-Ming Zhang et al.
PloS one, 8(3), e59234-e59234 (2013-04-05)
Substance P (SP) and its receptor, the neurokinin 1 receptor (NK1R), play important roles in transmitting and regulating somatosensory nociceptive information. However, their roles in visceral nociceptive transmission and regulation remain to be elucidated. In the previous study, moderate SP