A5330
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester
≥99% (TLC), powder
Synonym(s):
L-732,138
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About This Item
Empirical Formula (Hill Notation):
C22H18F6N2O3
CAS Number:
Molecular Weight:
472.38
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
SMILES string
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc3cc(cc(c3)C(F)(F)F)C(F)(F)F
InChI key
BYYQYXVAWXAYQC-IBGZPJMESA-N
assay
≥99% (TLC)
form
powder
mp
147-148 °C (lit.)
storage temp.
−20°C
Gene Information
human ... TACR1(6869)
Biochem/physiol Actions
Competitive substance P receptor antagonist.
Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC50 for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Takenori Onaga et al.
Regulatory peptides, 173(1-3), 64-73 (2011-10-06)
The present study investigated a role of tachykinins (TK) and neurokinin (NK) receptors (NK-R) in the non-cholinergic regulation of omasal contractions in sheep. Semiquantitative reverse transcription (RT)-PCR revealed that both preprotachykinin (PPT)-A and PPT-B mRNA were distributed in the omasal
Ammar Boudaka et al.
European journal of pharmacology, 556(1-3), 157-165 (2006-12-13)
Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, has been suggested to mediate the inhibitory effect of capsaicin on vagally mediated striated muscle contractions in the
Miguel Muñoz et al.
Peptides, 38(2), 318-325 (2012-10-03)
The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development
Francesco Ferrini et al.
Pain, 129(1-2), 195-209 (2007-02-24)
Inhibitory neurotransmission in spinal cord dorsal horn is mainly mediated by gamma-amino butyric acid (GABA) and glycine. By patch clamp recordings and correlative immunocytochemistry, we studied here the effect of 2 microM capsaicin-induced vanilloid receptor-1 (TRPV1) activation on IPSCs in
Luca Antonioli et al.
International journal of obesity (2005), 43(2), 331-343 (2018-08-08)
The murine model of high fat diet (HFD)-induced obesity is characterized by an increment of intestinal permeability, secondary to an impairment of mucosal epithelial barrier and enteric inflammation, followed by morphofunctional rearrangement of the enteric nervous system. The present study
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