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A5638

Adenosine 2′,5′-diphosphate sodium salt

≥95%, powder

Synonym(s):

2′-Phosphoadenosine 5′-phosphate sodium salt

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About This Item

Empirical Formula (Hill Notation):
C10H15N5O10P2 · xNa+
CAS Number:
154146-84-6
Molecular Weight:
427.20 (free acid basis)
MDL number:
MFCD05662190
UNSPSC Code:
41106305
PubChem Substance ID:
24891005
NACRES:
NA.51
Assay:
≥95%
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless to faintly yellow
Storage temp.:
−20°C
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Product Name

Adenosine 2′,5′-diphosphate sodium salt, ≥95%

Quality Level

200

assay

≥95%

form

powder

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3OP(O)(O)=O

InChI

1S/C10H15N5O10P2.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(25-27(20,21)22)6(16)4(24-10)1-23-26(17,18)19;/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22);

InChI key

OHPUPSOOFQPMRP-UHFFFAOYSA-N

Related Categories

Application

Adenosine 2′,5′-diphosphate may be used to study the mechanisms and activities of these components. Adenosine 2′,5′-diphosphate may be used to prepare adenosine 2′,5′-diphosphate agarose for affinity chromatography purification of enzymes such as NADPH-cytochrome P450 reductase and glutathione reductase.

Biochem/physiol Actions

Adenosine 2′,5′-diphosphate (A2P5P) is a competitive antagonist of the P2Y1 receptor and a non-selective antagonist of the platelet P2X1 ion channel. A2P5P prevents ADP-induced platelet aggregation and deformation but it does not affect ADP-induced inhibition of adenylyl cyclase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000486769
0000486769
0000486781
0000486781
SLBV4841

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F Moccia et al.
Microvascular research, 61(3), 240-252 (2001-05-05)
Intracellular Ca2+ signals elicited by nucleotide agonists were investigated in primary cultures of rat cardiac microvascular endothelial cells using the fura-2 technique. UTP increased the intracellular [Ca2+] in 94% of the cells, whereas 2MeSATP was active in 32%. The rank
R G Stevens et al.
Planta, 211(4), 537-545 (2000-10-13)
Expression in transgenic tobacco (Nicotiana tabacum L.) of a pea (Pisum sativum L.) GOR2 cDNA, encoding an isoform of glutathione reductase (GOR2), resulted in a 3- to 7-fold elevation of total foliar glutathione reductase (GR) activity. The enzyme encoded by
J L Boyer et al.
Molecular pharmacology, 50(5), 1323-1329 (1996-11-01)
Although P2 receptors mediate a myriad of physiological effects of extracellular adenine nucleotides, study of this broad class of receptors has been compromised by a lack of P2 receptor-selective antagonist molecules. The adenine nucleotide-promoted inositol lipid hydrolysis response of turkey
The platelet P2 receptors
Platelets, 259-277 (2019)
The P2Y1 receptor antagonist adenosine-2',5'-diphosphate non-selectively antagonizes the platelet P2X1 ion channel.
E Toth-Zsamboki et al.
Thrombosis and haemostasis, 86(5), 1338-1339 (2002-01-31)
View All Related Papers

Global Trade Item Number

SKUGTIN
A5638-25MG04061833258361
A5638-5MG04061833258378

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