A5922
Amifostine trihydrate
≥97% (TLC), powder
Synonym(s):
2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721
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About This Item
Empirical Formula (Hill Notation):
C5H15N2O3PS · 3 H2O
CAS Number:
Molecular Weight:
268.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
TXQPXJKRNHJWAX-UHFFFAOYSA-N
SMILES string
OP(SCCNCCCN)(O)=O.O.O.O
InChI
1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
assay
≥97% (TLC)
form
powder
storage temp.
2-8°C
Quality Level
Application
Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.
Biochem/physiol Actions
Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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V Vendramini et al.
Human reproduction (Oxford, England), 27(8), 2457-2466 (2012-05-18)
In a previous study, we found that amifostine provides some protection to the seminiferous epithelium of prepubertal doxorubicin-treated male rats but does not improve their fertility status as adults. Based on these results, a long-term study was undertaken to evaluate
Marleen Melis et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(5), 749-753 (2012-04-13)
Megalin-mediated renal retention of radiolabeled somatostatin analogs may lead to nephrotoxicity during peptide receptor radionuclide therapy (PRRT). The cytoprotective agent amifostine protected rats from long-term nephrotoxicity after PRRT with (177)Lu-DOTA,Tyr(3)-octreotate. This study describes the direct effect of amifostine on kidney
C M Spencer et al.
Drugs, 50(6), 1001-1031 (1995-12-01)
Amifostine (WR-2721) was originally developed as a radioprotective agent. In animals, it protects normal tissues from the damaging effects of irradiation and, as shown in more recent studies, of several cytotoxic agents. Protection of tumours is generally reduced compared with
Low-dose antioxidant is sufficient to regulate pulmonary redox equilibration.
Kong Zhengdong et al.
Critical care medicine, 40(5), 1693-1694 (2012-04-19)
Catherine N Tchanque-Fossuo et al.
Plastic and reconstructive surgery, 129(4), 646e-655e (2012-03-30)
Radiotherapy, a cornerstone of head and neck cancer treatment, causes substantial morbidity to normal adjoining bone. The authors assessed the radioprotective effect of amifostine therapy on the mineralization of the mandible using micro-computed tomography. They hypothesized that amifostine would safeguard
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