A5922
Amifostine trihydrate
≥97% (TLC), powder
Synonym(s):
2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721
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About This Item
Empirical Formula (Hill Notation):
C5H15N2O3PS · 3 H2O
CAS Number:
Molecular Weight:
268.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (TLC)
Form:
powder
Quality Segment
assay
≥97% (TLC)
form
powder
storage temp.
2-8°C
SMILES string
OP(SCCNCCCN)(O)=O.O.O.O
InChI
1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2
InChI key
TXQPXJKRNHJWAX-UHFFFAOYSA-N
Application
Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.
Biochem/physiol Actions
Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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