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Merck
CN

A6339

N-Acetyl-Val-Glu-Ile-Asp-al

~99% (HPLC), powder

Synonym(s):

Ac-VEID-CHO

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About This Item

Empirical Formula (Hill Notation):
C22H36N4O9
CAS Number:
319494-39-8
Molecular Weight:
500.54
NACRES:
NA.32
PubChem Substance ID:
329770890
UNSPSC Code:
12352209
MDL number:
MFCD01318861

Key Documents

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Product Name

N-Acetyl-Val-Glu-Ile-Asp-al, ~99% (HPLC), powder

InChI

1S/C22H36N4O9/c1-6-12(4)19(22(35)24-14(10-27)9-17(31)32)26-20(33)15(7-8-16(29)30)25-21(34)18(11(2)3)23-13(5)28/h10-12,14-15,18-19H,6-9H2,1-5H3,(H,23,28)(H,24,35)(H,25,34)(H,26,33)(H,29,30)(H,31,32)/t12-,14-,15-,18-,19-/m0/s1

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N[C@@H](CC(O)=O)C=O

InChI key

KYUFGGNCJRWMDN-GOYXDOSHSA-N

assay

~99% (HPLC)

form

powder

color

white

solubility

H2O: 1 mg/mL

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CASP6(839)

Biochem/physiol Actions

Caspase 6 inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
067K1095
027K2186
120K1514
078H0569

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Ali Khoshnan et al.
PloS one, 4(6), e5768-e5768 (2009-06-03)
Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD). However, the environmental cues and signaling pathways that regulate Htt proteolysis are poorly understood. One stimulus may be the DNA damage that accumulates in neurons
Roman E Beloshistov et al.
The New phytologist, 218(3), 1167-1178 (2017-04-14)
Peptide hormones are implicated in many important aspects of plant life and are usually synthesized as precursor proteins. In contrast to animals, data for plant peptide hormone maturation are scarce and the specificity of processing enzyme(s) is largely unknown. Here
Callinice D Capo-chichi et al.
Molecular and cellular biology, 29(17), 4766-4777 (2009-07-08)
A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The developmentally regulated GATA6 transcription factor is
Dagmar E Ehrnhoefer et al.
PloS one, 6(11), e27680-e27680 (2011-12-06)
Aberrant activation of caspase-6 has recently emerged as a major contributor to the pathogeneses of neurodegenerative disorders such as Alzheimer's and Huntington disease. Commercially available assays to measure caspase-6 activity commonly use the VEID peptide as a substrate. However these
Gustavo Lemos Rocha et al.
Plant science : an international journal of experimental plant biology, 288, 110232-110232 (2019-09-16)
Seed coat is the tissue which establishes an interface between the seed inner tissues and external environment. Our group has shown that cowpea seed coat undergoes coordinated events of programmed cell death (PCD) during development. In relation to germinating seed
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