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Merck
CN

A6470

N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide

≥97% (HPLC), powder

Synonym(s):

Ac-IEPD-pNA

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About This Item

Empirical Formula (Hill Notation):
C28H38N6O11
CAS Number:
Molecular Weight:
634.63
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
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Product Name

N-Acetyl-Ile-Glu-Pro-Asp-p-nitroanilide, ≥97% (HPLC), powder

form

powder

InChI key

YXEIIOVAGGAMCZ-NYMCBPKFSA-N

SMILES string

CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C28H38N6O11/c1-4-15(2)24(29-16(3)35)27(42)31-19(11-12-22(36)37)28(43)33-13-5-6-21(33)26(41)32-20(14-23(38)39)25(40)30-17-7-9-18(10-8-17)34(44)45/h7-10,15,19-21,24H,4-6,11-14H2,1-3H3,(H,29,35)(H,30,40)(H,31,42)(H,32,41)(H,36,37)(H,38,39)/t15-,19-,20-,21-,24-/m0/s1

assay

≥97% (HPLC)

solubility

DMSO: soluble

shipped in

dry ice

storage temp.

−20°C

Quality Level

General description

Chromogenic substrate for caspase 8 and granzyme B.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Patrick Ho et al.
ACS synthetic biology, 6(8), 1484-1495 (2017-05-17)
Targeted therapies promise to increase the safety and efficacy of treatments against diseases ranging from cancer to viral infections. However, the vast majority of targeted therapeutics relies on the recognition of extracellular biomarkers, which are rarely restricted to diseased cells

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