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A6558

Sigma-Aldrich

L-Aspartic acid potassium salt

≥98% (HPLC)

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Synonym(s):
Potassium L-aspartate
Linear Formula:
HO2CCH2CH(NH2)CO2K
CAS Number:
1115-63-5
Molecular Weight:
171.19
EC Number:
214-226-4
MDL number:
MFCD00063085
eCl@ss:
32160406
PubChem Substance ID:
24891105
NACRES:
NA.77

Quality Level

200

Assay

≥98% (HPLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white

SMILES string

N[C@H](C([O-])=O)CC(O)=O.[K+]

InChI

1S/C4H7NO4.K/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);/q;+1/p-1/t2-;/m0./s1

InChI key

TXXVQZSTAVIHFD-DKWTVANSSA-M

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General description

L-aspartic acid is a non-essential amino acid.

Application

L-Aspartic acid potassium salt has been used:
  • to prepare perforated patch-clamp intracellular solution
  • in serum glutamate–oxaloacetate transaminase (SGOT) assay
  • as a component in an internal solution (IS) for mitoflash assay to detect mitochondrial flashes in permeabilized cells

Biochem/physiol Actions

L-Aspartic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist.
Potassium aspartate is capable of preventing ventricular arrhythmia in ischemic rabbit heart by decreasing transmural repolarization dispersion (TDR).
Principal neurotransmitter for fast synaptic excitation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Qiyang Gong et al.
Fish & shellfish immunology, 97, 359-366 (2019-12-24)
Bacterial infection severely impairs aquaculture development throughout the world. Despite the use of antibiotics to control bacterial infection, few other options are available especially in the area of complex ecosystem and various types of fish. In search for novel approaches
Jun Pu et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 28(5), 517-519 (2008-10-11)
The aim of this study was to determine if the potassium aspartate and magnesium (PAM) prevent reperfusion-induced ventricular arrhythmias (RIVA) in ischemia-reperfusion (IR) rabbit heart. Thirty rabbits were randomly divided into control, ischemia and PAM groups. Arterially-perfused rabbit left ventricular
Qadeer Aziz et al.
Bio-protocol, 10(1), e3478-e3478 (2020-01-05)
Cardiac pacemaker cells of the sino-atrial node are responsible for the initiation of the heart beat and express an array of ion channels. The patch-clamp technique is the gold standard method for investigating the function of ion channels expressed in
Natascha Sommer et al.
Science advances, 6(16), eaba0694-eaba0694 (2020-05-20)
Mitochondria play an important role in sensing both acute and chronic hypoxia in the pulmonary vasculature, but their primary oxygen-sensing mechanism and contribution to stabilization of the hypoxia-inducible factor (HIF) remains elusive. Alteration of the mitochondrial electron flux and increased
Enika Nagababu et al.
Methods in molecular biology (Clifton, N.J.), 610, 165-180 (2009-12-17)
Reactive oxygen species are implicated in many human diseases and aging process. Much of the evidence is based on experimental data indicating increasing rates of lipid peroxidation in disease states and the ameliorating effects of antioxidants. It is becoming increasingly
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Chromatograms

application for HPLC

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