Name: 4-Amidinophenylmethanesulfonyl fluoride hydrochloride
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₈H₉FN₂O₂S · HCl

CAS Number:

74938-88-8

Molecular Weight:

252.69

Beilstein:

9083148

MDL number:

MFCD00078902

UNSPSC Code:

12352202

PubChem Substance ID:

24891118

NACRES:

NA.77

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Assay

≥97% (silver nitrate titration)

form

powder

mp

190-191 ºC

solubility

H₂O: 50 mM (Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.)

storage temp.

−20°C

SMILES string

Cl[H].NC(=N)c1ccc(CS(F)(=O)=O)cc1

InChI

1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H

InChI key

KHLLRHIUKOJXLL-UHFFFAOYSA-N

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General description

4-Amidinophenylmethanesulfonyl fluoride hydrochloride is relatively nontoxic.

Application

4-Amidinophenylmethanesulfonyl fluoride hydrochloride has been used:

as a component of inhibitor cocktail for whole blood collection and separation of plasma
as a component of sodium dodecyl sulfate (SDS) sample buffer to prepare whole-cell extract
as a trypsin inhibitor to measure its inhibition efficiency and to determine the efficacy of the quantum dot fluorescence resonance energy transfer (FRET)-based enzymatic probes

Biochem/physiol Actions

4-Amidinophenylmethanesulfonyl fluoride hydrochloride (p-APMSF) can inhibit the trypsin-like proteinase produced by Fusarium culmorum. It is also capable of blocking bovine Factor Xa, human plasmin, and the human complement proteases, C1r and C1s.

Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM.

Irreversible inhibitor of serine proteases with lysine or arginine substrate specificities. Effective concentration 10-100 μM. Frequently used to characterize newly discovered proteases.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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