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Merck
CN

A6683

L-Aspartic acid sodium salt monohydrate

≥98% (TLC)

Synonym(s):

(S)-2-Aminobutanedioic acid sodium salt, Sodium L-aspartate

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About This Item

Linear Formula:
HO2CCH2CH(NH2)CO2Na · H2O
CAS Number:
323194-76-9
Molecular Weight:
173.10
Beilstein:
6101944
EC Number:
223-264-0
MDL number:
MFCD00152960
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24891129
NACRES:
NA.32

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Product Name

L-Aspartic acid sodium salt monohydrate, ≥98% (TLC)

Quality Level

200

Assay

≥98% (TLC)

form

powder

color

white

SMILES string

[Na+].[H]O[H].N[C@@H](CC(O)=O)C([O-])=O

InChI

1S/C4H7NO4.Na.H2O/c5-2(4(8)9)1-3(6)7;;/h2H,1,5H2,(H,6,7)(H,8,9);;1H2/q;+1;/p-1/t2-;;/m0../s1

InChI key

PPTHNBYUFXSJPS-JIZZDEOASA-M

Gene Information

human ... GRIN2A(2903)
rat ... GRIN2A(14811)

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General description

Aspartic acid is a non-essential amino acid. L-Aspartic acid is a dicarboxylic amino acid, which is involved in the synthesis of nerve cells proteins. It also stimulates the depolarization of nerve cell membranes. L-Aspartic acid acts as an amine donor for transamination reaction.

Application

L-Aspartic acid sodium salt monohydrate has been as a component of reservoir solution for crystallization.

Biochem/physiol Actions

Principal neurotransmitter for fast synaptic excitation.
Selective outflow of L-aspartic acid across the blood-brain barrier controls the level of L and D aspartic acid in the brain. Increased levels of L-aspartic acid in the brain results in excitatory neurotoxicity. Recent studies highlight that racemization of L-aspartic acid is followed by the determination of D:L ratio to estimate the age of an individual.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7392V
WXBF7042V
0000472424
0000472424
0000455196

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Molecular interactions of some non-essential amino acids in aqueous solutions of 1-methylimidazolium chloride at different temperatures
Gaba R, et al.
Journal of Molecular Liquids (2019)
Design and characterization of erwinia chrysanthemi l-asparaginase variants with diminished l-glutaminase activity
Nguyen HA, et al.
The Journal of biological chemistry, 291(34), 17664-17676 (2016)
The Biological Effects of Glutamic Acid and Its Derivatives (2012)
Structural insight into substrate selectivity of Erwinia chrysanthemi l-Asparaginase
Nguyen HA, et al.
Biochemistry, 55(8), 1246-1253 (2016)
The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood?brain barrier
Kazuhiro Tetsuka
Journal of Neurochemistry, 87(4), 891-901 (2003)
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