A6719
ω-Agatoxin IVA
≥90% (HPLC)
Synonym(s):
SNX 290
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C217H360N68O60S10
CAS Number:
Molecular Weight:
5202.25
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
Quality Level
assay
≥90% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
Gene Information
human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)
Related Categories
General description
CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13.
Application
ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays.
Biochem/physiol Actions
Mutations in the CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene is responsible for episodic ataxia 2, familial hemiplegic migraine type 1 (FHM1) and spinocerebellar ataxia type 6 (SCA6).
Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels.
Features and Benefits
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
T J Turner et al.
Science (New York, N.Y.), 258(5080), 310-313 (1992-10-09)
Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been difficult to characterize because most presynaptic terminals are too small to probe with electrodes, and available pharmacological tools such as dihydropyridines and omega-conotoxin are
I M Mintz et al.
Neuron, 9(1), 85-95 (1992-07-01)
The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons (KD approximately 2 nM) but had no effect on identified T-type, L-type, or N-type currents in a variety of central and peripheral neurons. omega-Aga-IVA blocked a substantial
Charge-balanced biphasic electrical stimulation inhibits neurite extension of spiral ganglion neurons
Shen N, et al.
Neuroscience Letters, 624, 92-99 (2016)
Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura
Terwindt G M, et al.
Neurology, 56(8), 1028-1032 (2001)
New CACNA1A deletions are associated to migraine phenotypes
Grieco GS, et al.
The Journal of Headache and Pain, 19(1), 75-75 (2018)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A6719-.1MG | 04061833616369 |
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service