A7075
Adrenocorticotropic Hormone rat
≥95% (HPLC)
Synonym(s):
Adrenocorticotropic hormone fragment 1-39, Corticotropin A
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About This Item
Empirical Formula (Hill Notation):
C210H315N57O57S
CAS Number:
Molecular Weight:
4582.16
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
Biological source:
rat
Form:
powder
Assay:
≥95% (HPLC)
biological source
rat
sterility
non-sterile
assay
≥95% (HPLC)
form
powder
solubility
1% acetic acid: 1.00-1.04 mg/mL, clear, colorless, water: 1.00-1.04 mg/mL, clear, colorless
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Quality Level
Gene Information
rat ... Pomc(24664)
Biochem/physiol Actions
Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.
Other Notes
Lyophilized from 0.1% TFA in H2O
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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Hasan Arrat et al.
PloS one, 10(5), e0125638-e0125638 (2015-05-09)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology and pathology that makes the development of new therapies difficult. ACTH has neurotrophic and myotrophic effects, but has not been tested in an ALS mouse model. The G93A-SOD1
Carla Schulz et al.
American journal of physiology. Endocrinology and metabolism, 298(2), E237-E244 (2009-11-19)
ACTH and alpha-melanocyte-stimulating hormone (alpha-MSH) are both consecutively processed from proopiomelanocortin (POMC), which is synthesized in hypothalamic arcuate neurons innervating the paraventricular nuclei (PVN). POMC secretion/synthesis is regulated by energy availability. ACTH and alpha-MSH bind with equal affinity to melanocortin-4
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