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A7111

Acepromazine maleate

Name: Acepromazine maleate
Brand: SIGMA

≥98% (HPLC), ABCG2 inhibitor, powder

Synonym(s):

Acetopromazine maleate salt, 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine maleate salt, Acepromazine maleate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₂N₂OS · C₄H₄O₄

CAS Number:

3598-37-6

Molecular Weight:

442.53

NACRES:

NA.77

PubChem Substance ID:

329770915

UNSPSC Code:

12352200

EC Number:

222-748-9

MDL number:

MFCD00082473

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

protect from light

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Properties

Product Name

Acepromazine maleate, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

H₂O: >10 mg/mL

storage temp.

room temp

SMILES string

OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O

InChI

1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

FQRHOOHLUYHMGG-BTJKTKAUSA-N

Description

Application

Acepromazine maleate has been used:

as a component of anesthesia cocktail to test its effects on behavioral changes in rats
as a component of anesthesia cocktail to study its effects on lung resistance of rats
as an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells

Biochem/physiol Actions

Acepromazine is a phenothiazine antipsychotic comonly used as a veterinary drug (horses, dogs and cats). The compound is an analogue antipsychotic drug chlorpromazine (#C8138). The drug is thought to block receptors of dopamine in the brain. Recently it was discover that the compound inhibits ABCG2 transported protein, which overexpression in tumors is associated with drug resistance.

Atypical neuroleptic.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS06

signalword

Danger

hcodes

H301,H336

pcodes

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Global Trade Item Number

SKU	GTIN
A7111-10MG	04061833383568
A7111-50MG	04061832071534