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A7219

L-Aspartic acid

Name: <SC>L</SC>-Aspartic acid
Brand: SIGMA

from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

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Synonym(s):

(S)-(+)-Aminosuccinic acid, (S)-Aminobutanedioic acid

Linear Formula:

HO₂CCH₂CH(NH₂)CO₂H

CAS Number:

56-84-8

Molecular Weight:

133.10

Beilstein:

1723530

EC Number:

200-291-6

MDL number:

MFCD00002616

eCl@ss:

32160406

PubChem Substance ID:

24891191

NACRES:

NA.75

biological source

non-animal source

Quality Level

300

Agency

meets EP testing specifications
meets USP testing specifications

Assay

98.5-101.0%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

mp

>300 °C (dec.) (lit.)

solubility

1 M HCl: 100 mg/mL

SMILES string

N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI key

CKLJMWTZIZZHCS-REOHCLBHSA-N

Gene Information

human ... CA1(759) , CA2(760)
rat ... Grin2a(24409)

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Related Categories

Amino Acids

General description

Aspartic acid(ASP)/aspartate, a non-essential amino acid, is naturally produced by mammals. ASP is one of the 20 building-block amino acids of proteins and has a one letter code, D. L-Aspartic acid can be manufactured industrially by an enzymatic process using the aspartase enzyme.

Application

L-Aspartic acid has been used:

as an aspartame (ASP) metabolite to determine acetylcholinesterase (AChE) activity in the hippocampal homogenate of suckling rats
as printed chemotaxis ligands to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR) and nuclear magnetic resonance (NMR)
as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) for supplementation assays of various cultured cell lines

Biochem/physiol Actions

Principal neurotransmitter for fast synaptic excitation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Aspartic acid

Johnson EC

reference module in biomedical sciences (2017)

Amino acid production

Eggeling L and Sahm H

Comprehensive Biotechnology (2011)

Identification of Ligand-Receptor Interactions: Ligand Molecular Arrays, SPR and NMR Methodologies.

Christopher J Day et al.

Methods in molecular biology (Clifton, N.J.), 1512, 51-63 (2016-11-26)

Despite many years of research into bacterial chemotaxis, the only well characterized system to date is that of E. coli. Even for E. coli, the direct ligand binding had been fully characterized only for aspartate and serene receptors Tar and

Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition.

Hongyu Ding et al.

Science advances, 7(47), eabk1023-eabk1023 (2021-11-18)

[Figure: see text].

Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells.

Shota Someya et al.

iScience, 24(2), 102090-102090 (2021-02-23)

Human pluripotent stem cells (hPSCs) have a unique metabolic signature for maintenance of pluripotency, self-renewal, and survival. Although hPSCs could be potentially used in regenerative medicine, the prohibitive cost associated with large-scale cell culture presents a major barrier to the

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Chromatograms

HPLC Analysis of Aspartic Acid Enantiomers on Astec^® CHIROBIOTIC^® T (Methanol Mobile Phase)

application for HPLC

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