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A7603

Aculeacin A

from Aspergillus aculeatus, ≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C50H81N7O16
CAS Number:
58814-86-1
Molecular Weight:
1036.22
NACRES:
NA.85
PubChem Substance ID:
329770935
UNSPSC Code:
41116107
MDL number:
MFCD01674009
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biological source

Aspergillus aculeatus

Quality Segment

200

assay

≥95% (HPLC)

form

powder

solubility

DMSO: 10 mg/mL, DMF: soluble, ethanol: soluble, methanol: soluble

antibiotic activity spectrum

yeast

mode of action

cell wall synthesis | interferes

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@@H](O)C[N@H]3C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c4ccc(O)cc4)[C@@H](C)O

InChI

1S/C50H81N7O16/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-36(63)51-33-24-35(62)46(69)55-48(71)40-41(64)27(2)25-57(40)50(73)38(29(4)59)53-47(70)39(43(66)42(65)30-19-21-31(60)22-20-30)54-45(68)34-23-32(61)26-56(34)49(72)37(28(3)58)52-44(33)67/h19-22,27-29,32-35,37-43,46,58-62,64-66,69H,5-18,23-26H2,1-4H3,(H,51,63)(H,52,67)(H,53,70)(H,54,68)(H,55,71)/t27-,28+,29+,32+,33-,34-,35+,37-,38-,39-,40-,41-,42-,43-,46+/m0/s1

InChI key

YKPHLXGEPNYRPY-ZIUFDZNVSA-N

Application

Aculeacin A is used to study mutations that lead to antibiotic resistance in Saccharomyces cerevisiae , the inhibition of Candida albicans, and the morphogenetic transformation of Candida albicans when treated .

Biochem/physiol Actions

Aculeacin A, an amphophilic antibiotic, inhibits the biosynthesis of β−glucan by selective blockage of β(1→3) glucan synthase.
Aculeacin A is a lipopeptide that inhibits β-glucan synthesis in yeasts. The inhibition is due to the selective blockage of glucan synthase.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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