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A7861

Asenapine maleate

Name: Asenapine maleate
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12btetrahydro-1Hdibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-2-butenedioate, Org 5222, trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₆ClNO ·C₄H₄O₄

CAS Number:

85650-56-2

Molecular Weight:

401.84

MDL number:

MFCD00900588

UNSPSC Code:

12352200

PubChem Substance ID:

329770943

EC Number:

288-064-8

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H₂O: ≥10 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.CN1C[C@H]2[C@H](C1)c3cc(Cl)ccc3Oc4ccccc24

InChI

1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1

InChI key

GMDCDXMAFMEDAG-CHHFXETESA-N

Description

General description

Asenapine maleate acts as an antimanic. It belongs to the family of dibenzoxepinopyrrolidines. Asenapine is considered to be a weak inhibitor of cytochrome P450 2D6 (CYP2D6). It increases the level of dopamine, norepinephrine and acetylcholine in brain.

Application

Asenapine maleate has been used as a stressor in studying the Fos expression in forebrain structures of rat models.

Asenapine maleate is a serotonin 5-HT and dopamine D2 receptor antagonist. Asenapine maleate can be used to treat schizophrenia and bipolar mania.

Biochem/physiol Actions

Asenapine maleate is a 5-HT receptor antagonist (5-HT_1A,_1B, 5-HT_{2A, 2B, 2C}, 5-HT_5A, 5-HT₆ and 5-HT₇), a D2 antagonist, and an antipsychotic.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.