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A7926

Azlocillin sodium salt

Name: Azlocillin sodium salt
Brand: SIGMA

Synonym(s):

D-α-([Imidazolidin-2-on-1-yl]carbonylamino)benzylpenicillin

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About This Item

Linear Formula:

C₂₀H₂₂N₅O₆SNa

CAS Number:

37091-65-9

Molecular Weight:

483.47

NACRES:

NA.85

PubChem Substance ID:

24891295

UNSPSC Code:

51282412

EC Number:

253-347-7

MDL number:

MFCD07793330

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form

powder

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

room temp

SMILES string

[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C20H23N5O6S.Na/c1-20(2)13(17(28)29)25-15(27)12(16(25)32-20)22-14(26)11(10-6-4-3-5-7-10)23-19(31)24-9-8-21-18(24)30;/h3-7,11-13,16H,8-9H2,1-2H3,(H,21,30)(H,22,26)(H,23,31)(H,28,29);/q;+1/p-1/t11-,12-,13+,16-;/m1./s1

InChI key

UVOCNBWUHNCKJM-XFAPPKAWSA-M

General description

Chemical structure: β-lactam

Application

Azlocillin is often used against <l>Pseudomonas aeruginosa </l>and has been used to develop novel antibiotic quantitation techniques .

Biochem/physiol Actions

Azlocillin is a semisynthetic penicillin and a β-lactam antibiotic. It acts by inhibition of penicillin-binding protein (PBP)-dependent bacterial cell wall synthesis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

pictograms

GHS08

signalword

Danger

hcodes

H317,H334

pcodes

P280 - P302 + P352

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品

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Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31.

Venkata Raveendra Pothineni et al.

Scientific reports, 10(1), 3798-3798 (2020-03-04)

Lyme disease is one of most common vector-borne diseases, reporting more than 300,000 cases annually in the United States. Treating Lyme disease during its initial stages with traditional tetracycline antibiotics is effective. However, 10-20% of patients treated with antibiotic therapy

High-pressure liquid chromatographic quantitation of azlocillin.

A Weber et al.

Antimicrobial agents and chemotherapy, 24(5), 750-753 (1983-11-01)

We describe a rapid, precise, and simple procedure for the quantitation of azlocillin in serum and in aqueous solutions by high-pressure, reverse-phase liquid chromatography. This method uses a single precipitation step, detection by dual-wavelength monitoring (220 and 254 nm), and

Structure-Activity Relationships of Different β-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase.

Andrea M. Hujer, Malgosia Kania, et. Al

Journal of Affective Disorders, 49, 612-618 (2005)

Global Trade Item Number

SKU	GTIN
A7926-1G	04061833390771
A7926-5G	04061834400424
A7926-250MG	04061834427735

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