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A8727

Antalarmin hydrochloride

Name: Antalarmin hydrochloride
Brand: SIGMA

≥98% (HPLC), solid, CRF1 antagonist

Synonym(s):

N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₄N₄·HCl

CAS Number:

220953-69-5

Molecular Weight:

415.01

UNSPSC Code:

12352200

PubChem Substance ID:

24724401

NACRES:

NA.77

MDL number:

MFCD05664721

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

desiccated

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Properties

Product Name

Antalarmin hydrochloride, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C

InChI

1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H

InChI key

CGDGXEDXEXACKQ-UHFFFAOYSA-N

Description

Application

Antalarmin hydrochloride has been used:

to study its effect on stress-induced tryptophan hydroxylase 2 activity
to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation
to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Biochem/physiol Actions

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Features and Benefits

This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000426191

0000329663

0000266925

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Global Trade Item Number

SKU	GTIN
A8727-10MG	04061832895673
A8727-50MG	04061832895680